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首页> 外文会议>2012 IEEE International Workshop on Genomic Signal Processing and Statistics >Integrative analysis of methylation and gene expression data in TCGA
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Integrative analysis of methylation and gene expression data in TCGA

机译：TCGA中甲基化和基因表达数据的综合分析

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An integrative analysis of methylation and gene expression is performed using TCGA data for 997 samples from multiple cancer types. We use conditional mutual information to examine each gene separately, identify 798 genes whose expression are repressed by their methylation, and derive gene-specific thresholds to dichotomize their methylation data. For each methylation controlled gene, we evaluate its conditional correlation with other genes, and infer which other genes are its regulators or targets. The resulting set of regulator genes is much larger than that of target genes, and the set of regulator genes is highly enriched by transcription factors.
机译：使用TCGA数据对来自多种癌症类型的997个样品进行了甲基化和基因表达的综合分析。我们使用条件共有信息来分别检查每个基因，鉴定798个基因的表达被其甲基化抑制的基因，并推导特定于基因的阈值以将其甲基化数据二分。对于每个甲基化控制的基因，我们评估其与其他基因的条件相关性，并推断哪些其他基因是其调控因子或靶标。产生的调节基因组比目标基因大得多，并且调节基因组被转录因子高度富集。

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