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首页> 外文会议>2014 IEEE Conference on Biomedical Engineering and Sciences >Technological advancements in characterizing single cell's stiffness properties- A review
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Technological advancements in characterizing single cell's stiffness properties- A review

机译：表征单电池刚度特性的技术进步-综述

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摘要

Biophysical properties of living cells certainly play important roles for intra and intercellular biological events. However, conventional population approaches obscured cells heterogeneity and assume all cells are similar. With the introduction of single cell analysis, this limitation is slowly rectified by defining crucial methods to further revealing cell-to-cell variability. Research in biomechanics leads to better elucidation of cellular and molecular changes due to disease progression i.e diseased cell exhibits different mechanical properties as compared to healthy ones. This paper highlights on various technological advancements available for single cell stiffness characterizations and analytical comparison of the reviewed methods will be thoroughly discussed. In addition, several applications intended for early disease detection were presented.
机译：活细胞的生物物理特性对于细胞内和细胞间生物学事件当然起着重要作用。但是，传统的种群方法掩盖了细胞异质性，并假定所有细胞都是相似的。随着单细胞分析的引入，通过定义进一步揭示细胞间变异性的关键方法，这一局限性逐渐得到纠正。生物力学方面的研究可以更好地阐明由于疾病进展而引起的细胞和分子变化，即与健康细胞相比，患病细胞具有不同的机械性能。本文重点介绍了可用于单细胞刚度表征的各种技术进步，并将全面讨论所审查方法的分析比较。此外，还提出了一些用于早期疾病检测的应用程序。

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