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Technological advancements in characterizing single cell's stiffness properties- A review

机译：单细胞僵硬特性的技术进步 - 评论

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Biophysical properties of living cells certainly play important roles for intra and intercellular biological events. However, conventional population approaches obscured cells heterogeneity and assume all cells are similar. With the introduction of single cell analysis, this limitation is slowly rectified by defining crucial methods to further revealing cell-to-cell variability. Research in biomechanics leads to better elucidation of cellular and molecular changes due to disease progression i.e diseased cell exhibits different mechanical properties as compared to healthy ones. This paper highlights on various technological advancements available for single cell stiffness characterizations and analytical comparison of the reviewed methods will be thoroughly discussed. In addition, several applications intended for early disease detection were presented.
机译：活细胞的生物物理特性肯定会在内的内细胞和细胞内生物事件发挥重要作用。 然而，常规种群接近模糊的细胞异质性，并且假设所有细胞都是相似的。 随着单细胞分析的引入，通过限定关键方法进一步揭示细胞对细胞变异性来缓慢整流该限制。 生物力学的研究导致由于疾病进展引起的细胞和分子变化更好地阐明I.E患病细胞与健康的细胞表现出不同的机械性能。 本文突出了各种技术进步，可用于单细胞僵硬特征，并彻底讨论审查方法的分析比较。 此外，提出了用于早期疾病检测的几种应用。

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