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首页> 外文会议>219th National Meeting of the American Chemical Society; Mar 26-30, 2000; San Francisco, California >Modulation of Two Second Messengers in Bitter Taste Transduction of Agriculturally Relevant Compounds
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Modulation of Two Second Messengers in Bitter Taste Transduction of Agriculturally Relevant Compounds

机译：在农业相关化合物的苦味传递中调节两个第二信使

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摘要

The formation of chemical cellular signals in response to taste stimulation may be initiated in sub-second time range. We are using a Quench Flow Module (QFM) and a Fast Pippeting System (FPS) to monitor cellular signals in rat taste tissue homogenates and intact cells in response to bitter taste stimulants that are important to the acceptance of agricultural food products. Stimulation by grape-derived catechin and the citrus-derived naringin increased the formation of the IP_3 signal with parallel decline of cAMP. Under similar experimental conditions, the citrus-derived limonin reduced cAMP whereas casein-derived cyclo(Leu-Trp) bitter dipeptide produced a rapid and transient increase of cAMP. cGMP was not affected by any of the four stimuli. These results further emphasize the presence of multiple transduction pathways and modulation of two parallel second messengers in bitter taste sensation of some bitter compounds.
机译：响应于味觉刺激的化学细胞信号的形成可以在亚第二时间范围内开始。我们正在使用骤冷流动模块（QFM）和快速配管系统（FPS）来监测大鼠味觉组织匀浆和完整细胞中的细胞信号，以响应对味觉刺激物的刺激，这些刺激物对于接受农业食品非常重要。葡萄来源的儿茶素和柑橘来源的柚皮苷刺激增加了IP_3信号的形成，同时使cAMP下降。在相似的实验条件下，柑橘来源的柠檬苦素降低了cAMP，而酪蛋白来源的环（Leu-Trp）苦味二肽产生了cAMP的快速而短暂的增加。 cGMP不受四种刺激中的任何一种影响。这些结果进一步强调了在某些苦味化合物的苦味感觉中存在多个转导途径和两个平行的第二信使的调节。

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