Key uncertainties in risk informed standards for B. anthracis

机译：炭疽杆菌风险通报标准的主要不确定性

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After a series of bioterrorism-related anthrax attacks in 2001, how to accurately estimate the risk of mortality after exposure to B. anthracis is a major concern. Since in many cases human health risk from biological agents is associated with aerosol exposures, concentrations found on surfaces may be used to infer future or past aerosol exposures. In this paper, we assume that B. anthracis spores were released in a one compartment office suite which was connected by HVAC system. A sensitivity analysis is conducted to indentify the key parameters and uncertainties in assessing surface concentration corresponding to certain risk. This provides a background analysis for prioritizing research aimed at reducing these uncertainties.

机译：在2001年发生了一系列与生物恐怖主义有关的炭疽袭击之后，如何准确估算暴露于炭疽杆菌后的死亡风险是一个主要问题。由于在许多情况下，来自生物制剂的人类健康风险与气溶胶暴露有关，因此可以使用表面上发现的浓度来推断未来或过去的气溶胶暴露。在本文中，我们假设炭疽芽孢杆菌孢子在通过HVAC系统连接的一个隔室办公室套件中释放。进行敏感性分析以确定在评估与某些风险相对应的表面浓度时的关键参数和不确定性。这为优先考虑减少这些不确定性的研究提供了背景分析。

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来源
《The 2nd International Conference on Risk Analysis and Crisis Response(第二届风险分析与危机反应国际学术研讨会)》|2009年|252-257|共6页
会议地点 Beijing(CN);Beijing(CN)
作者
Tao Hong; Patrick L. Gurian;
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作者单位

Drexel University, Philadelphia, PA, USA;

Drexel University, Philadelphia, PA, USA;

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会议组织
原文格式 PDF
正文语种 eng
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关键词
Bioterrorism; environmental sampling; research priorities;

机译：生物恐怖主义;环境抽样;研究重点;

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专利

1. Setting Risk-Informed Environmental Standards for Bacillus Anthracis Spores [J] . Tao Hong, Patrick L. Gurian, Nicholas F. Dudley Ward Risk analysis . 2010,第10期

机译：为炭疽芽孢杆菌孢子制定风险告知环境标准
2. Gene expression profiling of human alveolar macrophages infected by B. anthracis spores demonstrates TNF-α and NF-κb are key components of the innate immune response to the pathogen [J] . Mikhail Dozmorov, Wenxin Wu, Kaushik Chakrabarty, BMC Infectious Diseases . 2009,第1期

机译：炭疽芽孢杆菌孢子感染人肺泡巨噬细胞的基因表达谱表明TNF-α和NF-κb是对病原体先天免疫反应的关键成分
3. Gene expression profiling of human alveolar macrophages infected by B. anthracis spores demonstrates TNF-α and NF-κb are key components of the innate immune response to the pathogen [J] . Mikhail Dozmorov, Wenxin Wu, Kaushik Chakrabarty, BMC Infectious Diseases . 2009,第1期

机译：炭疽芽孢杆菌孢子感染人肺泡巨噬细胞的基因表达谱表明TNF-α和NF-κb是对病原体先天免疫反应的关键成分
4. Key uncertainties in risk informed standards for B. anthracis [C] . International conference on risk analysis and crisis response . 2009

机译：风险风险的关键不确定性B. Anthracis的知情标准
5. B. anthracis peptidoglycan activates human innate immune cells and platelets through Fcgamma receptors and complement proteins. [D] . Sun, Dawei. 2013

机译：炭疽芽孢杆菌肽聚糖通过Fcγ受体和补体蛋白激活人类先天免疫细胞和血小板。
6. Gene expression profiling of human alveolar macrophages infected by B. anthracis spores demonstrates TNF-α and NF-κb are key components of the innate immune response to the pathogen [O] . Mikhail Dozmorov, Wenxin Wu, Kaushik Chakrabarty, 2009

机译：炭疽芽胞杆菌孢子感染人肺泡巨噬细胞的基因表达谱表明TNF-α和NF-κb是对病原体先天免疫反应的关键成分
7. Gene expression profiling of human alveolar macrophages infected by B. anthracis spores demonstrates TNF-α and NF-κb are key components of the innate immune response to the pathogen [O] . Dozmorov, Mikhail, Wu, Wenxin, Chakrabarty, Kaushik, 2009

机译：炭疽芽胞杆菌孢子感染人肺泡巨噬细胞的基因表达谱表明，TNF-α和NF-κb是对病原体先天免疫反应的关键成分

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Key uncertainties in risk informed standards for B. anthracis

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