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首页> 外文会议>3rd frontiers in biomedical devices conference 2008 : Imaging and anatomic interaction ; Simulation and testing ; Device testing ... >COMPUTATIONAL MECHANICS OF THE SCLERA AND OPTIC NERVE HEAD (ONH):EFFECTS OF ONH SIZE AND PRESSURE RANGE
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COMPUTATIONAL MECHANICS OF THE SCLERA AND OPTIC NERVE HEAD (ONH):EFFECTS OF ONH SIZE AND PRESSURE RANGE

机译：巩膜和视神经头（ONH）的计算机制：ONH大小和压力范围的影响

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Computational modeling was performed to study how loss of compliance of the eye and abnormally high pressures result in changes in stresses and strains that may impact the optic nerve in diseases such as glaucoma. Hemispherical finite element models of the eye were created in which scleral thickness varied from the equatorial region to the optic nerve head (ONH). Nonhomogeneous material properties were used to model the ONH as a continuous region softer than the adjacent sclera. The ONH and an adjacent buffer zone in the sclera were modeled with enough detail that the size of the ONH could be changed to account for variations observed in humans. The model was provided with appropriate dimensions typical of patients and nonlinear material properties with decreased compliance. Models with different ONH sizes were inflated in small steps to 55 mmHg (7.33 kPa), providing deformed configurations at intermediate pressures of 15, 30 and 45 mmHg, respectively.rnColor-coded maps of stress and strain components were rendered directly on deformed configurations of the eye model; and animations were produced that show both spatial and temporal variations of stresses and strains as internal pressure increases. Three-dimensional stresses and accompanying finite strains were similar for ONH sizes ranging form 1.5 to 2.5 mm in diameter. Stress and strain differences were estimated as pressure was increased from 15 to 25 mmHg, 30 to 40 mmHg, and 45 to 55 mmHg. Substantial changes occurred in stress and strain differences as the pressure range was varied with large changes occurring in the lowest pressure range for strain components and moderate increases in stress differences as pressures increase.
机译：进行了计算建模，以研究眼睛的顺应性丧失和异常高压如何导致压力和劳损的变化，这些变化可能会影响青光眼等疾病的视神经。创建了眼睛的半球有限元模型，其中巩膜厚度从赤道区域到视神经头（ONH）变化。使用非均质材料属性将ONH建模为比相邻巩膜更软的连续区域。对ONH和巩膜中的相邻缓冲区进行了足够详细的建模，可以更改ONH的大小以解决人类观察到的变化。该模型具有典型的患者尺寸和非线性材料特性，且顺应性降低。将具有不同ONH尺寸的模型小幅充气至55 mmHg（7.33 kPa），分别在15、30和45 mmHg的中间压力下提供变形配置。rn应力和应变分量的彩色编码图直接绘制在眼睛模型并制作了动画，显示随着内部压力的增加，应力和应变的时空变化。对于ONH尺寸范围为直径1.5到2.5 mm的三维应力和伴随的有限应变是相似的。当压力从15到25 mmHg，30到40 mmHg和45到55 mmHg升高时，估计应力和应变差异。随着压力范围的变化，应力和应变差异发生了实质性变化，应变分量的最低压力范围发生了较大变化，并且随着压力的增加，应力差异出现了适度的增加。

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