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首页> 外文会议>3rd International EMF Seminar in China: Electromagnetic Fields and Biological Effects; Oct 13-17, 2003; Guilin, China >THE CLUSTERING OF GROWTH FACTOR AND CYTOKINE FACTOR RECEPTORS WAS INDUCED BY 50 HZ MAGNETIC FIELD AND BLOCKED BY NOISE MAGNETIC FIELD
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THE CLUSTERING OF GROWTH FACTOR AND CYTOKINE FACTOR RECEPTORS WAS INDUCED BY 50 HZ MAGNETIC FIELD AND BLOCKED BY NOISE MAGNETIC FIELD

机译：生长因子和细胞因子因子受体的聚集被50 HZ磁场诱导并被噪声磁场阻止

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摘要

To study the possible effects of 50Hz magnetic field (MF) exposure on clustering of cell surface receptors, explore the mechanism of signal transduction of ELF-MF and confirm whether or not the noise magnetic fields (MF) interfere these effects induced by 50 Hz MF. Chinese Hamster Lung (CHL) cells were respectively exposed to 50Hz MF, noise MF with 0.4 mT, and combined MF which was superstition of 50 Hz MF with noise MF for different exposure durations (5, 15 and 30 min). Cells treated with 100ng/ml epidermal growth factor (EGF) or 10ng/ml tumor necrosis factor (TNF) for 15 min served as positive control. The clustering of EGF and TNF receptor was analyzed with confocal microscope. The results showed that, like the EGF and TNF, 50 Hz MF at 0.4 mT could obviously induce the clustering of cell surface receptors after exposure for 5 min, while the noise MF alone with the same intensity did not induce receptor clustering. When surperposed of noise MF with the same intensity, the receptor clustering induced by 50Hz MF was inhibited. It suggested that the membrane receptors would be the target sites where MF interacts with cell, and the noise MF could interfere these effects.
机译：为了研究50Hz磁场（MF）暴露对细胞表面受体聚集的可能影响，探索ELF-MF的信号转导机制，并确认噪声磁场（MF）是否干扰50 Hz MF诱导的这些影响。将中国仓鼠肺（CHL）细胞分别暴露于50Hz MF，0.4 mT的噪声MF以及在不同的暴露持续时间（5、15和30分钟）下结合50 Hz MF和噪声MF的混合MF。用100ng / ml表皮生长因子（EGF）或10ng / ml肿瘤坏死因子（TNF）处理15分钟的细胞作为阳性对照。用共聚焦显微镜分析EGF和TNF受体的聚集。结果表明，与EGF和TNF一样，在暴露5分钟后，0.4 mT的50 Hz MF可以明显诱导细胞表面受体聚集，而强度相同的噪声MF则不能诱导受体聚集。当以相同强度的噪声MF叠加时，抑制了50Hz MF诱导的受体聚集。这表明膜受体将是MF与细胞相互作用的靶位点，而MF噪声可能会干扰这些作用。

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