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首页> 外文会议>Advanced Biomedical and Clinical Diagnostic and Surgical Guidance Systems XV >Lymphatic imaging in unsedated infants and children
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Lymphatic imaging in unsedated infants and children

机译：未镇静的婴儿和儿童的淋巴成像

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Primary lymphedema and lymphatic malformations in the pediatric population remains poorly diagnosed and misunderstood due to a lack of information on the underlying anatomy and function of the lymphatic system. Diagnostics for the lymphatic vasculature are limited, consisting of lymphoscintigraphy or invasive lymphangiography, both of which require sedation that can restrict use in infants and children. As a result, therapeutic protocols for pediatric patients with lymphatic disorders remain sparse and with little evidence to support them. Because near-infrared fluorescence (NIRF) imaging enables image acquisition on the order of tenths of seconds with trace administration of fluorescent dye, sedation is not necessary. The lack of harmful radiation and radioactive contrast agents further facilitates imaging. Herein we summarize our experiences in imaging infants and children who are suspected to have disorders of the lymphatic vascular system using indocyanine green (ICG) and who have developed chylothorax following surgery for congenital heart defects. The results show both anatomical as well as functional lymphatic deficits in children with congenital disease. In the future, NIRF lymphatic imaging could provide new opportunities to tailor effective therapies and monitor responses. The opportunity to use expand NIRF imaging for pediatric diagnostics beyond the lymphatic vasculature is also afforded by the rapid acquisition following trace administration of NIRF contrast agent.
机译：由于缺乏有关淋巴系统的基本解剖结构和功能的信息，小儿人群的原发性淋巴水肿和淋巴管畸形仍然很难诊断和误解。淋巴管系统的诊断是有限的，包括淋巴造影或有创淋巴管造影，这两种方法均需要镇静剂，可能会限制婴儿和儿童的使用。结果，用于淋巴疾病的小儿患者的治疗方案仍然很少，并且没有证据支持它们。由于近红外荧光（NIRF）成像可以在痕量荧光染料的情况下获取十分之一秒的图像，因此无需镇静。有害辐射和放射性对比剂的缺乏进一步促进了成像。本文中，我们总结了使用吲哚菁绿（ICG）对怀疑患有淋巴管系统疾病且先天性心脏缺陷手术后出现乳糜胸的婴儿和儿童进行成像的经验。结果显示，先天性疾病儿童的解剖和功能性淋巴功能不全。将来，NIRF淋巴成像可能会提供新的机会，以量身定制有效的疗法并监测反应。在微量施用NIRF造影剂后快速采集也提供了将扩展的NIRF成像用于淋巴管系统以外的儿科诊断的机会。

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