• 主题
高级搜索  >
历史搜索 清空历史
首页> 外文会议>Advanced Biomedical and Clinical Diagnostic Systems IV; Progress in Biomedical Optics and Imaging; vol.7 no.3 >Early diagnosis of diabetic vascular complications: impairment of red blood cell deformability
【24h】

Early diagnosis of diabetic vascular complications: impairment of red blood cell deformability

机译：糖尿病血管并发症的早期诊断：红细胞变形性受损

获取原文
获取原文并翻译 | 示例
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

Reduced deformability of red blood cells (RBCs) may play an important role on the pathogenesis of chronic vascular complications of diabetes mellitus. However, available techniques for measuring RBC deformability often require washing process after each measurement, which is not optimal for day-to-day clinical use at point of care. The objectives of the present study are to develop a device and to delineate the correlation of impaired RBC deformability with diabetic nephropathy. We developed a disposable ektacytometry to measure RBC deformability, which adopted a laser diffraction technique and slit rheometry. The essential features of this design are its simplicity (ease of operation and no moving parts) and a disposable element which is in contact with the blood sample. We studied adult diabetic patients divided into three groups according to diabetic complications. Group Ⅰ comprised 57 diabetic patients with normal renal function. Group Ⅱ comprised 26 diabetic patients with chronic renal failure (CRF). Group Ⅲ consisted of 30 diabetic subjects with end-stage renal disease (ESRD) on hemodialysis. According to the renal function for the diabetic groups, matched non-diabetic groups were served as control. We found substantially impaired red blood cell deformability in those with normal renal function (group Ⅰ) compared to non-diabetic control (P = 0.0005). As renal function decreases, an increased impairment in RBC deformability was found. Diabetic patients with chronic renal failure (group Ⅱ) when compared to non-diabetic controls (CRF) had an apparently greater impairment in RBC deformability (P = 0.07). The non-diabetic cohort (CRF), on the other hand, manifested significant impairment in red blood cell deformability compared to healthy control (P = 0.0001). The newly developed slit ektacytometer can measure the RBC deformability with ease and accuracy. In addition, progressive impairment in cell deformability is associated with renal function loss in all patients regardless of the presence or absence of diabetes. In diabetic patients, early impairment in RBC deformability appears in patients with normal renal function.
机译：红细胞（RBCs）变形能力的降低可能在糖尿病慢性血管并发症的发病机理中起重要作用。但是，用于测量RBC变形能力的可用技术通常在每次测量后都需要清洗过程，这对于护理点的日常临床使用而言并不是最佳的。本研究的目的是开发一种设备并描述受损的RBC变形性与糖尿病性肾病的相关性。我们开发了一种一次性细胞计数仪来测量RBC的可变形性，它采用了激光衍射技术和狭缝流变仪。这种设计的基本特征是其简单性（操作简便，没有活动部件）以及与血液样本接触的一次性元件。我们研究了根据糖尿病并发症分为三组的成年糖尿病患者。 Ⅰ组包括57例肾功能正常的糖尿病患者。 Ⅱ组包括26例患有慢性肾功能衰竭（CRF）的糖尿病患者。第三组由30名糖尿病患者进行血液透析终末期肾脏疾病（ESRD）组成。根据糖尿病组的肾功能，配对非糖尿病组作为对照。与非糖尿病对照组相比，肾功能正常的患者（Ⅰ组）发现红细胞变形能力明显受损（P = 0.0005）。随着肾功能的下降，发现RBC变形能力的损害增加。与非糖尿病对照组（CRF）相比，患有慢性肾功能衰竭的糖尿病患者（Ⅱ组）的RBC变形能力明显受损（P = 0.07）。另一方面，与健康对照组相比，非糖尿病队列（CRF）在红细胞变形能力方面表现出明显的损害（P = 0.0001）。新开发的狭缝式血细胞计数器可以轻松，准确地测量RBC的变形能力。另外，无论是否存在糖尿病，所有患者的细胞变形能力的进行性损害均与肾功能丧失有关。在糖尿病患者中，肾功能正常的患者出现RBC畸形的早期损害。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号