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首页> 外文会议>Advances in bioceramics and porous ceramics III >GRAPE~? TECHNOLOGY OR BONE-LIKE APATITE DEPOSITION IN NARROW GROOVES
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GRAPE~? TECHNOLOGY OR BONE-LIKE APATITE DEPOSITION IN NARROW GROOVES

机译：葡萄〜？窄沟槽中的技术或类似磷灰石的沉积

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摘要

Among several techniques proposed for fixing titanium bone implant in bone tissues by inducing apatite deposition on the implant surface, "GRAPE~? Technology" is the simplest one, where optimum size of macro-grooving and heating in air are provided for pure titanium because samples with such grooves deposit apatite when soaked in an aqueous solution mimicking human blood plasma. The technique is needed to be confirmed by in vivo tests if it is effective for bone tissues, or if it is applicable to newly developed titanium alloy systems.rnIn this study, the validity of GRAPE~? Technology for a Ti-15Zr-4Ta-4Nb alloy was assessed with both in vitro and in vivo experiments. Here, alloy pieces with macro-grooves 500 μm in depth and 500 μm in width were heated at 500 ℃ to induce thin titania layers on the surface. In vivo tests confirmed bone-ingrowth within 3 weeks in the samples with the macro-grooves but very less for those without the grooves. Those results indicated that GRAPE~? Technology is effective for providing the Ti-15Zr-4Ta-4Nb-based implants with osteoconductivity.
机译：在通过诱导磷灰石在植入物表面上沉积而将钛骨植入物固定在骨组织中的几种提议的技术中，“ GRAPE〜？技术”是最简单的一种技术，其中为纯钛提供了最佳的宏观开槽尺寸和在空气中加热，因为样品当将这种凹槽浸入模拟人血浆的水溶液中时，会沉积磷灰石。该技术是否对骨骼组织有效，或者是否适用于新开发的钛合金系统，需要通过体内测试来确认。该研究中，GRAPE〜？的有效性。通过体外和体内实验对Ti-15Zr-4Ta-4Nb合金的技术进行了评估。在这里，将深度为500μm，宽度为500μm的大槽合金片在500℃下加热，在表面上形成薄的二氧化钛层。体内试验证实了具有大槽的样品在3周内可向骨内生长，而没有大槽的样品则很少。这些结果表明GRAPE〜？该技术有效地为基于Ti-15Zr-4Ta-4Nb的植入物提供了骨传导性。

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  • 来源
  • 会议地点 Daytona Beach FL(US);Daytona Beach FL(US)
  • 作者

    A. Sugino; K. Uetsuki; K. Kuramoto; S. Hayakawa; Y. Shirosaki; A. Osaka; K. Tsuru; T. Nakano; C. Ohtsuki;

  • 作者单位

    Nakashima Medical Co., Ltd 688-1 Joto-Kitagata, Higashi-ku, Okayama 709-0625, Japan;

    rnNakashima Medical Co., Ltd 688-1 Joto-Kitagata, Higashi-ku, Okayama 709-0625, Japan;

    rnNakashima Medical Co., Ltd 688-1 Joto-Kitagata, Higashi-ku, Okayama 709-0625, Japan;

    rnGraduate School of Natural Science and Technology Research Center for Biomedical Engineering, Okayama University Tsushima, Kita-ku, Okayama 700-8530, Japan;

    rnGraduate School of Natural Science and Technology Research Center for Biomedical Engineering, Okayama University Tsushima, Kita-ku, Okayama 700-8530, Japan;

    rnGraduate School of Natural Science and Technology Research Center for Biomedical Engineering, Okayama University Tsushima, Kita-ku, Okayama 700-8530, Japan;

    rnFaculty of Dental Science, Kyushu University Maidashi, Higashi-ku, F;

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  • 原文格式 PDF
  • 正文语种 eng
  • 中图分类 生物材料学;
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