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SR-XRF INVESTIGATION OF HUMAN BONE

机译:人体SR-XRF研究

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摘要

To investigate mineral and trace elements in human bone the micro-fluorescence facility installed at the bending magnet Beamline L at HASYLAB, Hamburg, was used, focusing our interest on differences in concentrations of lead between the outer (Substantia Compacta: SC) and inner bone region (Substantia Spongiosa: SS). Among mineral and heavy elements, Pb has been proven to exert adverse effects in men with T_(1/2) in human bone that ranges between 6-12 years. Thus, bone of a hip-operated adult patient was sliced perpendicular to the SC/SS transition and investigated. For the Pb detection, excitation with the synchrotron white spectrum to excite the K-shell and a monochromatic radiation obtained with the Si(111) channel cut to measure the L-shell fluorescence was compared. The monochromatic excitation delivered the best peak to background ratio and detection limits in sub ppm range. While the K-shell excitation did not reveal sufficient results, L-shell fluorescence was adequate with detection limits for Pb of 0.8ppm for white, and of 0.25ppm for monochromatic excitation respectively. From the medical point of view in the investigated bone sections, Pb, Ca, Fe and Zn were found in higher concentrations in SS than in SC, while Br and Ni, Cu seemed to be lower in the SS than in the SC area.
机译:为了研究人体骨骼中的矿物质和微量元素,使用了安装在汉堡HASYLAB弯曲磁铁Beamline L上的微荧光设备,我们的注意力集中在外骨骼(实质Compacta:SC)和内骨骼之间的铅浓度差异上。地区(海绵体:SS)。在矿物质和重金属元素中,Pb已被证明对6〜12岁之间的T_(1/2)人体骨骼产生不利影响。因此,将一名髋关节手术成年患者的骨骼垂直于SC / SS过渡切开并进行了研究。对于Pb的检测,比较了用同步加速器白色光谱激发K壳层和将Si(111)通道切割以测量L壳层荧光而获得的单色辐射。单色激发在亚ppm范围内提供了最佳的峰背景比和检测限。尽管K壳激发未显示出足够的结果,但L壳荧光足够了,白色的Pb检出限和单色激发的Pb检出限分别为0.25ppm和0.25ppm。从医学角度来看,在被研究的骨切片中,SS中的Pb,Ca,Fe和Zn含量高于SC,而SS中的Br和Ni,Cu似乎低于SC区域。

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  • 来源
  • 会议地点 Steamboat Springs CO(US);Steamboat Springs CO(US);Steamboat Springs CO(US)
  • 作者单位

    Atominstitut der (O)sterreichischen Universitdten, Stadionallee 2, A-1020 Vienna, Austria;

    rnAtominstitut der (O)sterreichischen Universitdten, Stadionallee 2, A-1020 Vienna, Austria;

    rnAtominstitut der (O)sterreichischen Universitdten, Stadionallee 2, A-1020 Vienna, Austria;

    rnAtominstitut der (O)sterreichischen Universitdten, Stadionallee 2, A-1020 Vienna, Austria;

    rnHASYLAB, DESY, Notkestrasse 85, D-22607 Hamburg, Germany;

    Universit?tsklinik für Innere Medizin IV, W?hringer Gürtel 18-20, A-1090 Vienna, Austria;

  • 会议组织
  • 原文格式 PDF
  • 正文语种 eng
  • 中图分类 X射线、紫外线、红外线;
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