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首页> 外文会议>Advances in optics for biotechnology, medicine and surgery XV >SCALABLE AND COST-EFFECTIVE OPTICAL COMPONENTS FOR BIOSENSING APPLICATIONS
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SCALABLE AND COST-EFFECTIVE OPTICAL COMPONENTS FOR BIOSENSING APPLICATIONS

机译：适用于生物传感应用的可扩展且经济高效的光学组件

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Cost-effectiveness has been a key factor in consumer biophotonics. In this talk, I will discuss two approaches for overall cost reduction. First, I will introduce a highly porous yet monolithic plasmonic nanosurface that features intense and high-density hot spots, large surface area, and high structural integrity and reproducibility. The fabrication process of this nanosurface is of low-cost and highly scalable. Using localized surface plasmon resonance (LSPR) and coupling modes, enhanced light-matter interactions near the nanosurface can be realized. The surface enhancement results in stronger signal which reduces the burden on high-end optical detection systems. We have applied them to several analytical Chem/Biosensing platforms for a range of sensing targets by various spectroscopic and imaging techniques. Nanoplasmonic sensors appear to provide potential solutions in a range of applications from precision medicine to point-of-care diagnostics and wearable technologies. In the second approach, we have developed an "inkjet printing" process for making polymer lenses which enable high quality microscopic imaging using smartphones - High performance microscopy of nanoscale objects and molecular species can be carried out on $10 phones. Finally, I will discuss the synergy of plasmonic enhancement and smartphone microscopy in the context of consumer biophotonics.
机译：成本效益一直是消费生物光子学的关键因素。在本次演讲中，我将讨论两种降低总体成本的方法。首先，我将介绍一个高度多孔但整体的等离激元纳米表面，该表面具有强烈且高密度的热点，较大的表面积以及较高的结构完整性和可重复性。该纳米表面的制造过程是低成本且高度可扩展的。使用局部表面等离子体共振（LSPR）和耦合模式，可以实现纳米表面附近增强的光-质相互作用。表面增强可以产生更强的信号，从而减轻了高端光学检测系统的负担。我们已将它们应用于通过各种光谱学和成像技术用于多种感测目标的多个分析化学/生物传感平台。纳米等离子体传感器似乎可以为从精密医学到即时诊断和可穿戴技术的一系列应用提供潜在的解决方案。在第二种方法中，我们开发了一种“喷墨印刷”工艺，用于制造聚合物镜片，从而可以使用智能手机进行高质量的显微成像-可以在10美元的手机上进行纳米级物体和分子种类的高性能显微术。最后，我将在消费生物光子学的背景下讨论等离子体增强与智能手机显微镜的协同作用。

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