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首页> 外文会议>Annual Biochemical Engineering Symposium; 20050423; Norman,OK(US) >Effect of blending with Polycaprolactone on the anti-bacterial properties of Chitosan for Periodontal Tissue Engineering
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Effect of blending with Polycaprolactone on the anti-bacterial properties of Chitosan for Periodontal Tissue Engineering

机译：聚己内酯共混物对壳聚糖对牙周组织工程抗菌性能的影响

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The aim of this work was to evaluate the anti-bacterial properties of chitosan and chitosan/polycaprolactone blend membranes against oral pathogens Streptococcus mutans and Actinobacillus actinomycetemcomitans. Membranes were suspended in bacterial cultures and incubated for 24hours. The bactericidal effect (by optical density measurements and agar plating) and bacterial adhesion (by digital imaging and scanning electron microscopy) of the membranes were studied. Results indicated that the presence of chitosan decreased the growth of both organisms in culture when compared to control (no membranes). This property was gradually compromised by the addition of PCL. SEM images indicated minimal presence of bacteria on chitosan. The adherence of bacteria increased steeply in 25%, 50% and 75% PCL respectively and pure PCL was almost covered with a biofilm-like layer of bacteria. Agar cultures indicated that chitosan does not allow bacterial viability and proliferation on its surface. In conclusion, the antibacterial properties of chitosan are compromised by blending with PCL, despite other advantages for tissue engineering applications.
机译：这项工作的目的是评估壳聚糖和壳聚糖/聚己内酯共混膜对口腔病原体变形链球菌和放线放线杆菌的抗菌性能。将膜悬浮在细菌培养物中并温育24小时。研究了膜的杀菌作用（通过光密度测量和琼脂平板）和细菌粘附（通过数字成像和扫描电子显微镜）。结果表明，与对照（无膜）相比，壳聚糖的存在会降低培养物中两种生物的生长。添加PCL逐渐损害了此属性。 SEM图像表明壳聚糖上细菌的最小存在。细菌的粘附率分别在25％，50％和75％的PCL中急剧增加，并且纯PCL几乎被生物膜样细菌覆盖。琼脂培养物表明，壳聚糖不允许细菌在其表面生存和繁殖。总之，尽管与组织工程应用有其他优势，但与PCL混合会损害壳聚糖的抗菌性能。

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