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首页> 外文会议>Asia-Pacific Conference on Environmental Electromagnetics (CEEM'2006) >Study of the ultrastructural changes in the thyroid gland of rats exposed to pulsed electromagnetic wave(PEMW)
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Study of the ultrastructural changes in the thyroid gland of rats exposed to pulsed electromagnetic wave(PEMW)

机译：脉冲电磁波（PEMW）照射对大鼠甲状腺超微结构变化的影响

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Objective To observe the effects of exposure to PEMW (Pulsed electromagnetic wave) on function and morphology of the Thyroid gland of rats. Methods At different time points (24h, 48h, 96h, 8d) after exposure to PEMW (E=115kV·m-1,12000pulses), radioimmunoassay was performed to observe the levels of thyroid-stimulating hormone (TSH), thyroxine (T4) and triiodothyronine(T3) in sera of those male SD rats; the optics microscope and the transmission electron microscope were used to observe the structural changes of thyroid gland as the indicated time points respectively. Results The T3、T4 and TSH in sera all increased significantly to the peak at 24h, then gradually decreased. Although there were no obvious changes under the optics microscope, some ultrastructral changes had been found under the transmission electron microscope in thyroid gland. Ultrastructures were obviously changed at 12h and aggravated after 12 h until 48 h. In these rats, dilatated endoplasmic reticulum gathered with lots of protein excretion, lipid droplet and the heterochromatin gathered under the nucleus membranes were observed in follicular epithelial cells. These changes were palliated at 96 h but not recovered. Conclusion PEMW can affect levels of hormones in sera and the hazard ultrastructual changes of thyroid gland. Endoplasmic reticulum is the main injured organelle.
机译：目的观察脉冲电磁波（PEMW）对大鼠甲状腺功能和形态的影响。方法在暴露于PEMW（E = 115kV·m-1,12000pulses）的不同时间点（24h，48h，96h，8d）进行放射免疫测定，观察​​甲状腺刺激激素（TSH），甲状腺素（T4）的水平雄性SD大鼠血清中的三碘甲状腺素（T3）；分别用光学显微镜和透射电子显微镜观察甲状腺的结构变化。结果血清中的T3，T4和TSH均在24h达到最高值，然后逐渐下降。尽管在光学显微镜下没有明显的变化，但是在透射电子显微镜下甲状腺中发现了一些超微结构的变化。超微结构在​​12h时明显改变，并在12h到48h后加剧。在这些大鼠中，在卵泡上皮细胞中观察到扩张的内质网聚集大量蛋白排泄，脂质滴和异染色质聚集在细胞膜下。这些变化在96 h缓解，但未恢复。结论PEMW可影响血清中激素水平和危害甲状腺超微结构变化。内质网是受伤的主要细胞器。

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