• 主题
高级搜索  >
历史搜索 清空历史
首页> 外文会议>Asilomar Conference on Signals, Systems, and Computers >Altered Structural Connection Between Hippocampus and Insula in Adolescent Major Depressive Disorder using DTI
【24h】

Altered Structural Connection Between Hippocampus and Insula in Adolescent Major Depressive Disorder using DTI

机译：使用DTI改变青少年青春期抑郁症患者海马体与岛突之间的结构联系

获取原文
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

The adolescent major depressive disorder is one of the top 10 debilitating psychiatric illnesses and the effectiveness of current treatment methods are constrained by the limited understanding of biological causes. In this paper, we use diffusion tensor imaging to explore changes in anatomical connectivity between the MDD group (n=37) and control group (n=27). Furthermore, along-track analysis is performed to identify locations of alterations along connections with significant connectivity change. For the connection between the hippocampus and the insular cortex in the right hemisphere, decreased connectivity in axial diffusivity (AD), mean diffusivity (MD), and radial diffusivity (RD) was discovered. Additionally, the number of tracks for the same connection is increased for the MDD group. Moreover, for the connection between the parahippocampal gyrus and the insular cortex in the left hemisphere, increased connectivity is observed in fractional anisotropy (FA), AD, MD, and RD. Furthermore, the locations of significant alterations are identified to be between 65% to 100% from the insular cortex to the hippocampus in the right hemisphere and at the 80% location from the insular cortex to the parahippocampal gyrus in the left hemisphere. The significant and consistent white matter changes at the hippocampus end of the insula-hippocampus connection suggest potential correlations to the previously reported grey matter shrinkage and functional abnormalities.
机译：青少年重度抑郁症是十大令人衰弱的精神疾病之一，目前对治疗方法的有效性受到对生物学原因的了解有限。在本文中，我们使用扩散张量成像来探索MDD组（n = 37）和对照组（n = 27）之间的解剖学连接性变化。此外，执行沿轨分析以识别沿具有重大连通性变化的连接的更改位置。对于右半球海马体和岛状皮层之间的连接，发现轴向扩散率（AD），平均扩散率（MD）和径向扩散率（RD）的连通性降低。此外，对于MDD组，用于同一连接的磁道数量增加了。此外，对于左半球海马旁回和岛状皮质之间的连接，在分数各向异性（FA），AD，MD和RD中观察到连接性增加。此外，在右半球从岛状皮层到海马的显着改变的位置被确定在65％至100％之间，在左半球从岛状皮层到海马旁回的80％位置。在岛状海马连接的海马末端显着且一致的白质变化提示与先前报道的灰质缩小和功能异常的潜在相关性。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号