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首页> 外文会议>ASME summer bioengineering conference;SBC2010 >A Fluid Structure Interaction Simulation of the Cerebrospinal Fluid, Spinal Cord, and Spinal Stenosis Present in Syringomyelia
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A Fluid Structure Interaction Simulation of the Cerebrospinal Fluid, Spinal Cord, and Spinal Stenosis Present in Syringomyelia

机译：脊髓空洞症中存在的脑脊髓液，脊髓和脊髓狭窄的流体结构相互作用模拟

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摘要

Syringomyelia (SM) is a neurological disease in which a fluid-filled cystic cavity, or syrinx, forms in the spinal cord (SC) resulting in progressive loss of sensory, motor functions, and/or pain in the patient. It has been hypothesized that abnormal cerebrospinal fluid (CSF) pressure distribution and absorption in the subarachnoid space (SAS), resulting from a CSF flow blockage (stenosis), could be a key etiological factor for syrinx pathogenesis. In particular, the magnitude of the abrupt SAS pressure waves produced during coughing has been correlated with headache and pain in the patient.To better understand the influence of coughing on the spinal SAS, four axisymmetric fluid-structure interaction (FSI) in silico models representative of various conditions associated with SM were constructed. Each of the models was subjected to a cough-like CSF pressure pulse.The CSF flow stenosis was shown to attenuate and decelerate the CSF wave propagation in the SAS. The spinal SAS distensibility was also shown to have significant influence on the wave propagation. The in silico pressure results were found to be in agreement with a set of similar in vitro experiments [1].
机译：脊髓空洞症（SM）是一种神经系统疾病，其中在脊髓（SC）中形成充满液体的囊性腔或syrinx，导致患者感觉，运动功能和/或疼痛的逐渐丧失。假设由于CSF流量阻塞（狭窄）而导致的蛛网膜下腔（SAS）中异常的脑脊髓液（CSF）压力分布和吸收可能是syrinx发病机理的关键病因。特别是，咳嗽过程中突然产生的SAS压力波的幅度与患者的头痛和疼痛有关。为了更好地了解咳嗽对脊柱SAS的影响，计算机模型中的四个轴对称流体-结构相互作用（FSI）代表构建了与SM相关的各种条件。每个模型都经历了类似咳嗽的CSF压力脉冲.CSF流动狭窄显示出可以减弱和减速SAS中CSF波的传播。脊柱SAS的可扩张性还显示出对波传播具有重要影响。发现计算机模拟结果与一组类似的体外实验一致[1]。

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