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首页> 外文会议>Bioceramics >A Study of Bone-Like Apatite Formation on β-TCP/PLLA Scaffold in Static and Dynamic Simulated Body Fluid
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A Study of Bone-Like Apatite Formation on β-TCP/PLLA Scaffold in Static and Dynamic Simulated Body Fluid

机译：静态和动态模拟体液中β-TCP/ PLLA支架上类似骨磷灰石形成的研究

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摘要

The ability of apatite to form on the surface of biomaterials in simulated body fluid (SBF) has been widely used to predict the bone-bonding ability of bioceramic and bioceramic/polymer composites in vivo. Porous β-tricalcium phosphate/poly(L-lactic acid) (β-TCP/PLLA) composite scaffold was synthesized by new method. The ability of inducing calcium phosphate (Ca-P) formation was compared in static simulated body fluid(sSBF) and dynamic simulated body fluid (dSBF). The Ca-P morphology and crystal structures were identified using SEM, X-ray diffraction and Fourier transform infrared (FT-IR) spectroscopy. The results showed that the typical features of bone-like apatite formation on the surface and the inner pore wall of β-TCP/PLLA. Ca-P formation on scaffold surfaces in dSBF occurred slower than in sSBF and was more difficult with increasing flow rate of dSBF. The ability of apatite to form on β-TCP/PLLA was enhanced by effect of each other that has different degradable mechanism. Porous β-TCP/PLLA composite scaffold indicates good ability of Ca-P formation in vitro.
机译：磷灰石在模拟体液（SBF）中的生物材料表面形成的能力已被广泛用于预测体内生物陶瓷和生物陶瓷/聚合物复合材料的骨结合能力。采用新方法合成了多孔β-磷酸三钙/聚L-乳酸（β-TCP/ PLLA）复合支架。比较了静态模拟体液（sSBF）和动态模拟体液（dSBF）诱导磷酸钙（Ca-P）形成的能力。使用SEM，X射线衍射和傅立叶变换红外（FT-IR）光谱鉴定了Ca-P的形态和晶体结构。结果表明，β-TCP/ PLLA的表面和内孔壁均具有骨状磷灰石形成的典型特征。在dSBF中，支架表面上的Ca-P形成要比sSBF中的形成速度慢，并且随着dSBF流速的增加而变得更加困难。磷灰石在β-TCP/ PLLA上形成的能力由于具有不同可降解机制的相互影响而得到增强。多孔的β-TCP/ PLLA复合支架表明体外Ca-P形成的良好能力。

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