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首页> 外文会议>Biomedical Engineering and Biotechnology (iCBEB), 2012 International Conference on >The Correlation between 1-deoxynojirimycin Content and alpha-glucosidase Inhibitory Activity in the Bark Ethanol Extract from Ramulus mori
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The Correlation between 1-deoxynojirimycin Content and alpha-glucosidase Inhibitory Activity in the Bark Ethanol Extract from Ramulus mori

机译：毛Ram树皮乙醇提取物中1-脱氧野oji霉素含量与α-葡萄糖苷酶抑制活性的相关性

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摘要

1-Deoxynojirimycin (DNJ) is a novel well known a-glucosidase inhibitor. We studied the relationships between a-glucosidase inhibitory activity and DNJ content in a bark ethanol extract (BEE) from Ramulus mori. Twenty cultivars of Ramulus mori, a shrub also known as mulberry branch, were used as experimental materials. Aqueous alcohol extraction methods were employed to obtain an ethanol extract from the branch bark powder. In vitro bioactivity assay indicated the 20 types of extracted BEE from mulberry branch had strong a-glucosidase inhibitory activity, with an IC50 value ranging from 3.89 to 22.91 µg/mL. The BEE IC50 values from the XiaoJiGuan and BaiGeLu cultivars were the highest and the lowest, respectively. The DNJ content in these extracts were measured using HPLC after DNJ derivation. The results showed these BEEs varied widely. The cultivar QingSang had the highest DNJ content while HuSang 32 had the lowest. Comparative analysis revealed no obvious correlation between 1-deoxynojirimycin (DNJ) content and a-glucosidase inhibitory activity of the BEEs (R=0.0085). These results indicate, aside from DNJ, other unexamined concerned constituents of the BEE from mulberry branch cultivars have significant a-glucosidase inhibitory activity.
机译：1-脱氧野oji霉素（DNJ）是一种新型的众所周知的α-葡萄糖苷酶抑制剂。我们研究了Ramulus mori树皮乙醇提取物（BEE）中α-葡萄糖苷酶抑制活性与DNJ含量之间的关系。实验材料是二十种拉姆鲁斯（Ramulus mori）灌木（一种灌木，也称为桑树分支）。采用水醇提取方法从分支树皮粉末中获得乙醇提取物。体外生物活性测定表明，从桑树分支中提取的20种BEE具有很强的α-葡萄糖苷酶抑制活性，IC50值在3.89至22.91 µg / mL之间。小蓟关和百格鲁品种的BEE IC50值分别最高和最低。 DNJ衍生后，使用HPLC测量这些提取物中的DNJ含量。结果表明，这些BEE差异很大。青桑品种的DNJ含量最高，而胡桑32品种的DNJ含量最低。对比分析显示，BEEs的1-deoxynojirimycin（DNJ）含量与α-葡萄糖苷酶抑制活性之间无明显相关性（R = 0.0085）。这些结果表明，除DNJ外，来自桑树分支品种的BEE的其他未经检查的相关成分具有显着的α-葡萄糖苷酶抑制活性。

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