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首页> 外文会议>Biomedical Science amp; Engineering Conference, 2009. BSEC 2009 >“A case for non-invasive, awake, nonanesthetized, unrestrained imaging”
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“A case for non-invasive, awake, nonanesthetized, unrestrained imaging”

机译：“非侵入性，清醒，非麻醉，不受约束的成像情况”

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摘要

For neurological conditions, the ability to image brain function during certain physiological conditions is important in elucidating developmental, behavioral, and disease state conditions. Accomplishing this entails imaging a subject in an awake and alert state, but this has its challenges. Primarily, the blurring effect of subject motion during imaging studies is a limiting factor. Until now, the options available to minimize this have been restricted to the use of chemical, e.g. anesthetics, and/or physical restraints such as attaching head immobilization hardware to minimize subject motion induced blurring. Because both physical and chemical restraints perturb normal brain function, the results thus obtained are biased. Furthermore, the plethora of available anesthesia and the varying imaging protocols make it difficult to compare study results both inter- and intra-study. Current efforts towards near-normal state, awake imaging will be presented along with preclinical results obtained from imaging mice.
机译：对于神经系统疾病，在阐明某些生理状况时对大脑功能成像的能力对于阐明发育，行为和疾病状态状况非常重要。要做到这一点，就需要对处于清醒和警觉状态的对象成像，但这有其挑战。首先，成像研究过程中对象运动的模糊效果是一个限制因素。迄今为止，使这种情况最小化的可用选项仅限于使用化学药品，例如麻醉和/或物理约束，例如连接头部固定硬件，以最大程度地减少对象运动引起的模糊。由于物理和化学限制都扰乱了正常的大脑功能，因此获得的结果存在偏差。此外，过多的可用麻醉和不同的成像方案使得很难在研究期间和研究期间比较研究结果。将介绍当前向接近正常状态，清醒成像的努力以及从成像小鼠获得的临床前结果。

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