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Activity of glycated chitosan and other adjuvants to PDT vaccines

机译：糖化壳聚糖和其他佐剂对PDT疫苗的活性

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Glycated chitosan (GC), a water soluble galactose-conjugated natural polysaccharide, has proven to be an effective immunoadjuvant for treatment of tumors based on laser thermal therapy. It was also shown to act as adjuvant for tumor therapy with high-intensity ultrasound and in situ photodynamic therapy (PDT). In the present study, GC was examined as potential adjuvant to PDT-generated cancer vaccine. Two other agents, pure calreticulin protein and acid ceramidase inhibitor LCL521, were also tested as prospective adjuvants for use in conjunction with PDT vaccines. Single treatment with GC, included with PDT vaccine cells suspension, improved the therapeutic efficacy when compared to vaccine alone. This attractive prospect of GC application remains to be carefully optimized and mechanistically elucidated. Both calreticulin and LCL521 proved also effective adjuvants when combined with PDT vaccine tumor treatment.
机译：糖化壳聚糖（GC）是一种水溶性半乳糖缀合的天然多糖，已被证明是基于激光热疗法治疗肿瘤的有效免疫佐剂。还显示它可作为高强度超声和原位光动力疗法（PDT）的肿瘤疗法的佐剂。在本研究中，GC被认为是PDT产生的癌症疫苗的潜在佐剂。还测试了另外两种药物，即纯钙网蛋白蛋白和酸性神经酰胺酶抑制剂LCL521，作为与PDT疫苗结合使用的前瞻性佐剂。与单独的疫苗相比，GC的单次治疗（包括PDT疫苗细胞悬浮液）提高了治疗效果。 GC应用的这一诱人前景仍然有待仔细优化和机制阐明。当与PDT疫苗肿瘤治疗联合使用时，钙网蛋白和LCL521均被证明也是有效的佐剂。

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