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首页> 外文会议>Biophotonics and immune responses X >Intravital imaging of multicolor-labeled tumor immune microenvironment through skin-fold window chamber
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Intravital imaging of multicolor-labeled tumor immune microenvironment through skin-fold window chamber

机译：通过皮肤折叠窗口腔室的彩色标记的肿瘤免疫微环境的活体成像

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摘要

Tumor immune microenvironment became very important for the tumor immunotherapy. There were several kinds of immune cells in tumor stromal, and they played very different roles in tumor growth. In order to observe the behaviors of multiple immune cells in tumor microenvironment and the interaction between immune cells and tumor cells at the same time, we generated a multicolor-labeled tumor immune microenvironment model. The tumor cells and immune cells were labeled by different fluorescent proteins. By using of skin-fold window chamber implanted into mice and intravital imaging technology, we could dynamically observe the different immune cells in tumor microenvironment. After data analysis from the video, we could know the behavior of TILs, DCs and Tregs in tumor immune microenvironment; furthermore, we could know these immune cells play different roles in the tumor microenvironment.
机译：肿瘤免疫微环境对于肿瘤免疫治疗变得非常重要。肿瘤基质中有几种免疫细胞，它们在肿瘤生长中起着非常不同的作用。为了观察肿瘤微环境中多种免疫细胞的行为以及免疫细胞与肿瘤细胞之间的相互作用，我们建立了一个多色标记的肿瘤免疫微环境模型。肿瘤细胞和免疫细胞被不同的荧光蛋白标记。通过使用植入小鼠的皮肤折叠窗口室和活体成像技术，我们可以动态观察肿瘤微环境中的不同免疫细胞。通过视频中的数据分析，我们可以了解肿瘤免疫微环境中TIL，DC和Treg的行为；此外，我们可以知道这些免疫细胞在肿瘤微环境中起着不同的作用。

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  • 来源
    《Biophotonics and immune responses X》|2015年|93240F.1-93240F.7|共7页
  • 会议地点 San Francisco CA(US)
  • 作者

    Shuhong Qi; Zhihong Zhang;

  • 作者单位

    Britton Chance Center for Biomedical Photonics, Wuhan National Laboratory for Optoelectronics, Huazhong University of Science and Technology, Wuhan 430074, China,MoE Key Laboratory for Biomedical Photonics, Department of Biomedical Engineering, Huazhong University of Science and Technology, Wuhan 430074, China;

    Britton Chance Center for Biomedical Photonics, Wuhan National Laboratory for Optoelectronics, Huazhong University of Science and Technology, Wuhan 430074, China,MoE Key Laboratory for Biomedical Photonics, Department of Biomedical Engineering, Huazhong University of Science and Technology, Wuhan 430074, China;

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  • 原文格式 PDF
  • 正文语种 eng
  • 中图分类
  • 关键词

    Intravital imaging; multicolor-labeled; tumor microenvironment; window chamber;

    机译：玻璃体内成像；多色标签；肿瘤微环境窗户室;

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