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The Combination of radiotherapy and immunotherapy using glycated chitosan as an immunological stimulant

机译：糖化壳聚糖作为免疫刺激剂的放疗与免疫疗法的结合

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摘要

Immunotherapy has been reported to effectively treat various cancers. In addition, scientists are dedicated in finding whether the combination of radiotherapy and immunotherapy can efficiently suppress cancer progression and recurrence. Although radiotherapy has been widely used for breast cancer, better strategies to overcome the late-stage breast cancer remains explored. The glycated chitosan (GC), a novel immunological stimulant, was demonstrated to trigger local immune response facilitating the enhancement of radiosensitivity. Our previous study also revealed that the cell mortality and invasive ability were decreased under GC treatment, but the underlying mechanism remains unclear. In this study, we used 4T1-3R-L, a derived murine breast cancer cell line from the spontaneous metastasized liver lesion. We combined ionizing radiation with GC to treat 4T1-3R-L and found the expression of DNA damage-related genes such as gamma-H2AX was more than radiation alone In addition, the cell cycle distribution and colony forming assay showed an increased sub-G1 population and decreased cell survival rate after IR combined GC treatment. Taken together, we sought to elucidate the underlying mechanism by the investigation of DNA damage repair process when IR combined with GC, and to explore another advantage of GC to aid other cancer treatments. Based on our most updated results, the GC treatment is able to effectively increase the radiosensitivity through an immune-responsive signaling transduction, indicating that GC could be a valuable therapeutic strategy for treating against advanced breast cancers.
机译：据报道，免疫疗法可有效治疗各种癌症。此外，科学家致力于发现放疗和免疫疗法的结合是否可以有效抑制癌症的进展和复发。尽管放疗已广泛用于乳腺癌，但仍在探索更好的策略来克服晚期乳腺癌。糖化壳聚糖（GC）是一种新型的免疫刺激剂，被证明可触发局部免疫反应，从而促进放射敏感性的增强。我们以前的研究还显示，在GC处理下，细胞死亡率和侵袭能力降低了，但其潜在机制仍不清楚。在这项研究中，我们使用了4T1-3R-L，这是一种自发转移肝脏病变的鼠类乳腺癌细胞系。我们将电离辐射与GC结合用于治疗4T1-3R-L，发现与DNA损伤相关的基因（如gamma-H2AX）的表达比单独的辐射还要多。此外，细胞周期分布和集落形成试验显示亚G1含量增加IR联合GC处理后细胞数量减少，细胞存活率降低。总之，我们试图通过研究IR与GC结合时DNA损伤修复过程来阐明其潜在机制，并探索GC协助其他癌症治疗的另一个优势。根据我们最新的结果，GC治疗能够通过免疫应答信号转导有效提高放射敏感性，表明GC可能是治疗晚期乳腺癌的有价值的治疗策略。

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  • 来源
    《Biophotonics and immune responses X》|2015年|932416.1-932416.5|共5页
  • 会议地点 San Francisco CA(US)
  • 作者

    Chun-Yuan Chang; Jyh-Der Leu; Chung-Yi Wang; Wei R. Chen; Yi-Jang Lee;

  • 作者单位

    DEPARTMENT OF BIOMEDICAL IMAGING AND RADIOLOGICAL SCIENCES, NATIONAL YANG-MING UNIVERSITY, TAIPEI, TAIWAN;

    DIVISION OF RADIATION ONCOLOGY, TAIPEI CITY HOSPITAL RENAI BRANCH, TAIPEI, TAIWAN;

    DEPARTMENT OF RADIOTHERAPY, CHENG HSIN GENERAL HOSPITAL, TAIPEI, TAIWAN;

    BIOPHOTONICS RESEARCH LABORATORY, DEPARTMENT OF ENGINEERING AND PHYSICS, UNIVERSITY OF CENTRAL OKLAHOMA, EDMOND, USA;

    DEPARTMENT OF BIOMEDICAL IMAGING AND RADIOLOGICAL SCIENCES, NATIONAL YANG-MING UNIVERSITY, TAIPEI, TAIWAN;

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  • 原文格式 PDF
  • 正文语种 eng
  • 中图分类
  • 关键词

    breast cancer; glycated chitosan; radiotherapy;

    机译：乳腺癌;糖化壳聚糖放射疗法;

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