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首页> 外文会议>Conference on reporters, markers, dyes, nanoparticles, and molecular probes for biomedical applications >Clinically Translatable Nanotheranostic Platforms for Peripheral Nerve Regeneration: Design with Outcome in Mind
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Clinically Translatable Nanotheranostic Platforms for Peripheral Nerve Regeneration: Design with Outcome in Mind

机译：临床可翻译的Nanotheranostic平台为周围神经再生：设计与结果的头脑。

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Neuroinflammation is a dynamic immune phenomenon that changes in severity with time after neurotrauma and has a profound impact on neuroregeneration, tissue healing and neuropathic pain, which is a common consequence of peripheral nerve injury (PNI). Macrophages are key cellular mediators of neuroinflammation. Macrophage-targeted nanotherapies, such as complex (perfluorocarbon/hydrocarbon) multimodal nanoemulsions (NEs) provide highly specific imaging signatures of neuroinflammation and hence indirect surrogate metrics of regeneration. We present a novel strategy where these NEs incorporating multiple imaging modalities and biosensors are delivered locally to directly target key cellular players of neuroregeneration. Two representative formulations of a nanotheranostic platform for local delivery of cell targeted NEs are presented: 1) A dual (macrophage and neuronal) targeted nanoparticle laden hydrogel for synergistic modulation of neuroinflammation and analgesia following PNI; and 2) neurotherapeutic loaded nanoparticles with extended release profile for sustained support of neuroregeneration. Each platform is capable of dual imaging payloads (NIRF, MRI and/or PET) and/or cell specific targeting moieties for controlled drug release. In vitro and pilot in vivo results will be presented. Theranostic nanosystem based platforms offer a unique opportunity to sequentially monitor cellular and molecular events at the site of neuronal injury, enabling dynamic, in-vivo mechanistic insights rather than static, ex-vivo histopathologic evaluation. Given their targeted capabilities, these platforms can help achieve personalized treatments that are customized and optimized for patients with PNI.
机译：神经发炎是一种动态免疫现象，在神经外伤后其严重程度会随着时间而改变，并且对神经再生，组织愈合和神经性疼痛产生深远影响，这是周围神经损伤（PNI）的常见后果。巨噬细胞是神经炎症的关键细胞介质。靶向巨噬细胞的纳米疗法，例如复杂的（全氟化碳/碳氢化合物）多峰纳米乳剂（NEs），可提供高度特异性的神经炎症成像特征，从而间接替代了再生指标。我们提出了一种新颖的策略，其中结合了多种成像方式和生物传感器的这些NE在本地交付，直接靶向神经再生的关键细胞。提出了两种用于局部递送靶向细胞的NE的纳米治疗平台的代表性制剂：1）双重（巨噬细胞和神经元）靶向纳米粒子负载水凝胶，用于在PNI后协同调节神经炎症和镇痛作用； 2）负载神经治疗剂的纳米颗粒，具有延长的释放曲线，以持续支持神经再生。每个平台都能够进行双重成像有效载荷（NIRF，MRI和/或PET）和/或细胞特异性靶向部分，以控制药物释放。将介绍体外和体内先导结果。基于治疗纳米系统的平台提供了独特的机会，可以顺序地监视神经元损伤部位的细胞和分子事件，从而实现动态的，体内机制的见解，而不是静态的，离体的组织病理学评估。鉴于其目标功能，这些平台可以帮助实现针对PNI患者定制和优化的个性化治疗。

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