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首页> 外文会议>Colloidal quantum dots for biomedical applications V >Immobilization of Quantum Dots in Multiple Responsive Microgels for Biomedical Applications
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Immobilization of Quantum Dots in Multiple Responsive Microgels for Biomedical Applications

机译：用于生物医学应用的多种反应性微凝胶中量子点的固定化

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摘要

A novel type of smart hybrid materials based on the in situ immobilization of quantum dots (QDs) on a responsive microgel template was prepared and investigated. Firstly, a temperature and pH dual responsive hybrid microgel was developed through the in-situ immobilization of CdS QDs in the interior of a copolymer microgel of poly(N-isopropylacrylamide-acrylamide-acrylic acid) [p(NIPAM-Aam-AA)]. The amino groups of the pAAm segments in the microgels are designed to sequester the precursor Cd~(2+) ions for in situ formation of CdS QDs in the interior of the microgels and stabilize the CdS QDs embedded in the microgels. We demonstrated that the carboxyl groups on the p(NIPAM-Aam-AA)-CdS hybrid microgels can be used for further coupling with 3-aminophenyl boronic acid for optical glucose sensing. The glucose concentration change can induce a reversible swelling/shrinkage of the hybrid microgels, which can further modify the physicochemical environment of the QDs immobilized inside the microgels, resulting in a reversible quenching/antiquenching in photoluminescence (PL). The method is extendable to other QDs with different emission wavelengths and other targeting ligands, thus it is possible to develop multifunctional hybrid micro-ano-gels for additional important biomedical applications.
机译：基于反应性微凝胶模板上的量子点（QDs）原位固定化的新型智能混合材料的制备和研究。首先，通过将CdS QDs原位固定在聚（N-异丙基丙烯酰胺-丙烯酰胺-丙烯酸）[p（NIPAM-Aam-AA）]共聚物微凝胶内部，开发了温度和pH双响应混合微凝胶。 。微凝胶中pAAm片段的氨基被设计为隔离前体Cd〜（2+）离子，以便在微凝胶内部原位形成CdS QD，并稳定嵌入微凝胶中的CdS QD。我们证明了p（NIPAM-Aam-AA）-CdS杂化微凝胶上的羧基可用于进一步与3-氨基苯基硼酸偶联以进行光学葡萄糖传感。葡萄糖浓度的变化可以引起杂化微凝胶的可逆溶胀/收缩，这可以进一步改变固定在微凝胶内部的QD的物理化学环境，从而导致光致发光（PL）发生可逆的淬灭/反猝灭。该方法可扩展到具有不同发射波长的其他QD和其他靶向配体，因此有可能开发用于其他重要生物医学应用的多功能杂化微/纳米凝胶。

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  • 来源
  • 会议地点 San Francisco CA(US)
  • 作者

    Weitai Wu; Ting Zhou; Michael Aiello; Shuiqin Zhou;

  • 作者单位

    Department of Chemistry and The Center for Engineered Polymeric Materials of College of Staten Island, and The Graduate Center, The City University of New York, 2800 Victory Boulevard, Staten Island, NY, USA 10314;

    Department of Chemistry and The Center for Engineered Polymeric Materials of College of Staten Island, and The Graduate Center, The City University of New York, 2800 Victory Boulevard, Staten Island, NY, USA 10314;

    Department of Chemistry and The Center for Engineered Polymeric Materials of College of Staten Island, and The Graduate Center, The City University of New York, 2800 Victory Boulevard, Staten Island, NY, USA 10314;

    Department of Chemistry and The Center for Engineered Polymeric Materials of College of Staten Island, and The Graduate Center, The City University of New Yor;

  • 会议组织
  • 原文格式 PDF
  • 正文语种 eng
  • 中图分类 医用物理学;
  • 关键词

    optical glucose sensing quantum dots smart hybrid microgels;

    机译：光学葡萄糖传感量子点智能混合微凝胶;

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