首页> 外文会议>Conference on Optical Design and Engineering; Sep 30-Oct 3, 2003; St.Etienne, France >Integrated optical coupling element for functional genomic analysis biosensor
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Integrated optical coupling element for functional genomic analysis biosensor

机译:功能基因组分析生物传感器的集成光耦合元件

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We present here a design of a coupling element aimed to be integrated into a nanomechanical biosensor for functional genomic analysis. The operation principle is based on a sub-nanometer resolution optical measurement of a cantilever deflection caused by a surface stress when the target nucleic acid sample hybridises to the nucleic acid probe on the active side of the cantilever. The resulting deflection, of the order of nanometers, is measured by an optical system, in which a laser beam reflects off the back of the cantilever to a position sensitive photo-detector. We study in this paper three polymer optical coupling systems which could allow to detect the presence of target nucleic acid on the cantilever by amplifying the deflection caused by the stress.
机译:我们在这里提出一种耦合元件的设计,旨在整合到用于功能基因组分析的纳米机械生物传感器中。操作原理基于亚纳米分辨率光学测量,该光学测量是当目标核酸样品与悬臂活性侧的核酸探针杂交时由表面应力引起的悬臂挠度。通过光学系统测量所产生的约纳米级的偏转,其中激光束从悬臂的背面反射到位置敏感的光电探测器。我们在本文中研究了三种聚合物光耦合系统,它们可以通过放大由应力引起的偏转来检测悬臂上靶核酸的存在。

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