• 主题
高级搜索  >
历史搜索 清空历史
首页> 外文会议>Conference on Optical Diagnostics of Living Cells Ⅴ, Jan 23-25, 2002, San Jose, USA >Thermal Energy Effects on Articular Cartilage: A Multidisciplinary Evaluation
【24h】

Thermal Energy Effects on Articular Cartilage: A Multidisciplinary Evaluation

机译：热能对关节软骨的影响：多学科评价

获取原文
获取原文并翻译 | 示例
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

Partial thickness articular cartilage lesions are commonly encountered in orthopedic surgery. These lesions do not have the ability to heal by themselves, due to lack of vascular supply. Several types of treatment have addressed this problem, including mechanical debridement and thermal chondroplasty. The goal of these treatments is to provide a smooth cartilage surface and prevent propagation of the lesions. Early thermal chondroplasty was performed using lasers, and yielded very mixed results, including severe damage to the cartilage, due to poor control of the induced thermal effects. This led to the development (including commercial) of probes using radiofrequency to generate the thermal effects desired for chondroplasty. Similar concerns over the quantitative aspects and control ability of the induced thermal effects in these treatments led us to test the whole range of complex issues and parameters involved. Our investigations are designed to simultaneously evaluate clinical conditions, instrument variables for existing radiofrequency probes (pressure, speed, distance, dose) as well as the associated basic science issues such as damage temperature and controllability (down to the subcellular level), damage geometry, and effects of surrounding conditions (medium, temperature, flow, pressure). The overall goals of this work are (1) to establish whether thermal chondroplasty can be used in a safe and efficacious manner, and (2) provide a prescription for multi-variable optimization of the way treatments are delivered, based on quantitative analysis. The methods used form an interdisciplinary set, to include precise mechanical actuation, high accuracy temperature and temperature gradient control and measurement, advanced imaging approaches and mathematical modeling.
机译：在骨科手术中通常会遇到部分厚度的关节软骨病变。这些病变由于缺乏血管供应而无法自行治愈。几种类型的治疗已经解决了这个问题，包括机械清创术和热软骨变性术。这些治疗的目的是提供光滑的软骨表面并防止病变扩散。早期的热软骨成骨术是使用激光进行的，由于对热效应的控制不佳，产生了非常混杂的结果，包括严重损害软骨。这导致开发（包括商业化）使用射频产生软骨弹性所需的热效应的探头。对这些处理中诱导的热效应的定量方面和控制能力的类似关注使我们测试了所涉及的复杂问题和参数的整个范围。我们的研究旨在同时评估临床状况，现有射频探头的仪器变量（压力，速度，距离，剂量）以及相关的基础科学问题，例如损伤温度和可控性（低至亚细胞水平），损伤几何形状，和周围条件（介质，温度，流量，压力）的影响。这项工作的总体目标是（1）确定是否可以安全有效地使用热软骨球疗法，以及（2）基于定量分析为治疗方式的多变量优化提供处方。所使用的方法形成了一个跨学科的集合，包括精确的机械驱动，高精度的温度和温度梯度控制和测量，先进的成像方法和数学建模。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号