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首页> 外文会议>Conference on Physiology and Function: Methods, Systems, and Applications Feb 16-18, 2003 San Diego, California, USA >Regional white matter volume and the relation with attentional functioning in survivors of malignant pediatric brain tumors
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Regional white matter volume and the relation with attentional functioning in survivors of malignant pediatric brain tumors

机译：恶性小儿脑肿瘤幸存者的区域白质量及其与注意功能的关系

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摘要

Quantitative assessment of MR examinations in 37 survivors of childhood cancer treated with central nervous system prophylaxis revealed that normal appearing white matter (NAWM) volume is associated with attention-related problems, localized specifically in the right prefrontal region. T1-, T2-, and PD-weighted images were segmented and divided into pre-frontal, frontal, parietal/temporal, and parietal/occipital regions for each hemisphere. These eight regions were analyzed in five slices centered at the level of the basal ganglia. The patient's age at diagnosis and time elapsed from diagnosis were used as covariates in the regressions. Attentional measures showed significant deficiency when compared to age and gender normative values. Total, frontal and/or prefrontal NAWM volumes from the range of slices examined were significantly associated with 5 of the 8 attentional measures. The frontal/prefrontal region of the brain is associated with executive functioning tasks and could potentially be spared as much as possible during therapy planning. The results of the present study further support the contention that NAWM is an important substrate for treatment-induced neurocognitive problems among survivors of malignant brain tumors of childhood.
机译：对37名接受中枢神经系统预防治疗的儿童癌症幸存者进行的MR检查的定量评估显示，正常出现的白质（NAWM）量与注意力相关的问题有关，特别是位于右前额叶区域。分割T1，T2和PD加权图像，然后将每个半球分为前额叶，额叶，顶叶/颞叶和顶叶/枕叶区域。对这八个区域进行了五个切片，这些切片以基底神经节的水平为中心。诊断时的患者年龄和诊断后的时间用作回归分析的协变量。与年龄和性别规范值相比，注意措施显示出明显的缺陷。来自所检查切片范围的总，额和/或额前NAWM量与8个注意措施中的5个显着相关。大脑的额叶/前额叶区域与执行功能任务相关联，在治疗计划期间可以尽可能多地保留下来。本研究结果进一步支持以下观点：NAWM是儿童恶性脑肿瘤幸存者中治疗引起的神经认知问题的重要基质。

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