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首页> 外文会议>Conference on Physiology and Function: Methods, Systems, and Applications Feb 16-18, 2003 San Diego, California, USA >Impact of local vessel curvature on the circumferential plaque distribution in coronary arteries
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Impact of local vessel curvature on the circumferential plaque distribution in coronary arteries

机译：局部血管曲率对冠状动脉周围斑块分布的影响

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摘要

Plaque in native coronary arteries is hypothesized to accumulate more likely along the inner curvature of a vessel segment as compared to its outer curvature. This behavior is likely associated with differences in local shear stress, which tends to be lower on the inner bend of a curved vessel than on the outer bend. The reported in-vivo study evaluated how the circumferential plaque distribution depends on local vessel curvature in coronaries from a limited set of 12 patients. Geometrically correct models of the vessel segments were generated utilizing fusion between biplane angiography and intravascular ultrasound. The plaque thickness was derived from the 3-D borders of the lumen/plaque and media/adventitia interfaces. Within each frame, plaque thickness was classified into "below-average" and "above-average" regions. A local curvature index was defined for each point: A positive value indicates the "inner" curvature, a negative value the "outer" curvature, with the magnitude determined from differential geometry. In the majority of the examined vessels, regions of "below-average/outer-curvature" and "above-average/inner-curvature" combined outweighed the "below-average/inner-curvature" and "above-average/outer-curvature" regions. The ratio increased with the threshold to exclude lower-curvature regions, confirming the hypothesis that plaque is more likely to accumulate on the luminal surface along the inner curvature of the coronary segment.
机译：假定天然冠状动脉中的斑块与其外曲率相比，更可能沿着血管段的内曲率积聚。此行为可能与局部剪切应力的差异有关，该应力在弯曲容器的内部弯曲处比在外部弯曲处要低。报道的体内研究评估了12名患者中一组的冠状动脉周围斑块分布如何取决于局部血管曲率。利用双平面血管造影术和血管内超声之间的融合产生了血管段的几何正确模型。斑块厚度来自管腔/斑块和介质/外膜界面的3-D边界。在每个框架内，斑块厚度被分类为“低于平均”和“高于平均”区域。为每个点定义了局部曲率指数：正值表示“内部”曲率，负值表示“外部”曲率，其大小由微分几何确定。在大多数检查的船只中，“低于平均/外部曲率”和“高于平均/内部曲率”的区域总和超过“低于平均/内部曲率”和“高于平均/外部曲率”的区域”区域。该比率随阈值的增加而增加，以排除较低曲率的区域，从而证实了这样的假设，即斑块更可能沿着冠状动脉节段的内曲率积聚在腔表面上。

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