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首页> 外文会议>Conference on Ultraviolet Ground- and Space-based Measurements, Models, and Effects, Jul 30-Aug 1, 2001, San Diego, USA >Ultraviolet B, Vitamin D and Their Mechanisms in Cancer Prevention
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Ultraviolet B, Vitamin D and Their Mechanisms in Cancer Prevention

机译：紫外线B，维生素D及其在癌症预防中的作用机制

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Background: Recent advances confirming the role of vitamin D in prevention of cancer have created a new field of scientific interest. The main source of vitamin D is exposure of the skin to ultraviolet light, and characteristics that reduce penetration of ultraviolet B (UVB) through the atmosphere play a major role in increasing risk of cancers of the colon, breast, and other sites. Objective: The objective of this project was to systematically review all epidemiological and laboratory studies concerning effects of UVB or vitamin D on colon and breast cancer. Methods: All published research articles identified in computer sources as measuring the role of ultraviolet B, vitamin D, and its metabolites in conjunction with colon and breast cancer were ascertained and abstracts or articles were reviewed. Epidemiological studies and experiments were examined and results were combined into summaries when possible. Results: The preponderance of epidemiological and laboratory studies support the hypothesis that moderate exposures to ultraviolet B and vitamin D provide important protection against colon and breast cancer, among others. The effect is present throughout life for colon cancer, but is exerted mostly during the first two decades of life for breast cancer. Conclusion: At latitudes above approximately 37°, climatological factors, sulfate air pollution, stratospheric ozone, and behavioral factors combine to reduce the dermal synthesis of vitamin D to virtually zero during winter months. These populations are therefore at markedly elevated risk of vitamin D deficiency, and, consequently, of colon and breast cancer incidence and mortality.
机译：背景：最近的研究证实了维生素D在预防癌症中的作用，创造了一个新的科学领域。维生素D的主要来源是皮肤暴露于紫外线下，减少紫外线B（UVB）通过大气渗透的特性在增加结肠癌，乳腺癌和其他部位的癌症风险中起着重要作用。目的：该项目的目的是系统地审查所有有关UVB或维生素D对结肠癌和乳腺癌的影响的流行病学和实验室研究。方法：确定所有在计算机资料来源中确定的测量紫外线B，维生素D及其代谢物与结肠癌和乳腺癌一起作用的已发表研究文章，并对摘要或文章进行综述。进行了流行病学研究和实验检查，并在可能的情况下将结果合并为摘要。结果：大量的流行病学和实验室研究支持以下假设：适度暴露于紫外线B和维生素D可为抵抗结肠癌和乳腺癌等提供重要保护。这种作用存在于结肠癌的整个生命中，但主要在乳腺癌的生命的前二十年中发挥作用。结论：在高于大约37°的纬度处，气候因素，硫酸盐空气污染，平流层臭氧和行为因素共同导致冬季维生素D的真皮合成减少到几乎为零。因此，这些人群维生素D缺乏症的风险显着升高，因此，结肠癌和乳腺癌的发病率和死亡率也大大增加。

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