Fluorinated Methionines as Probes in Biological Chemistry

机译：氟化蛋氨酸在生物化学中的应用

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Fluorinated analogs of the amino acid methionine have been synthesized and utilized as replacements for this amino acid in a variety of proteins. Application of ~(19)F nuclear magnetic resonance spectroscopy to these fluorinated proteins have increased our knowledge of protein structure and ligand binding events. As well, characterization of these fluorinated proteins using enzyme or bioactivity assays has indicated that little perturbation of the normal activity of the protein occurs upon incorporation of these analogs into proteins.

机译：已合成了氨基酸蛋氨酸的氟化类似物，并用作各种蛋白质中该氨基酸的替代物。〜（19）F核磁共振波谱在这些氟化蛋白质上的应用增加了我们对蛋白质结构和配体结合事件的了解。同样，使用酶或生物活性测定法对这些氟化蛋白质的表征表明，在将这些类似物掺入蛋白质后，几乎不会干扰蛋白质的正常活性。

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来源
《Current fluoroorganic chemistry : New synthetic directions, technologies, materials, and biological applications》|2005年|393-408|共16页
会议地点 Washington DC(US);Washington DC(US)
作者
John F. Honek;
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作者单位

Department of Chemistry, University of Waterloo, Waterloo, Ontario N2L 3G1, Canada;

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会议组织
原文格式 PDF
正文语种 eng
中图分类氟及其化合物;
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入库时间 2022-08-26 14:19:54

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Fluorinated Methionines as Probes in Biological Chemistry

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