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Assessment of imaging quality in magnified phase CT of human bone tissue at the nanoscale

机译：纳米级人骨组织放大CT成像质量评估

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摘要

Bone properties at all length scales have a major impact on the fracture risk in disease such as osteoporosis. However, quantitative 3D data on bone tissue at the cellular scale are still rare. Here we propose to use magnified X-ray phase nano-CT to quantify bone ultra-structure in human bone, on the new setup developed on the beamline ID16A at the ESRF, Grenoble. Obtaining 3D images requires the application of phase retrieval prior to tomographic reconstruction. Phase retrieval is an ill-posed problem for which various approaches have been developed. Since image quality has a strong impact on the further quantification of bone tissue, our aim here is to evaluate different phase retrieval methods for imaging bone samples at the cellular scale. Samples from femurs of female donors were scanned using magnified phase nano-CT at voxel sizes of 120 and 30 nm with an energy of 33 keV. Four CT scans at varying sample-to-detector distances were acquired for each sample. We evaluated three phase retrieval methods adapted to these conditions: Paganin's method at single distance, Paganin's method extended to multiple distances, and the contrast transfer function (CTF) approach for pure phase objects. These methods were used as initialization to an iterative refinement step. Our results based on visual and quantitative assessment show that the use of several distances (as opposed to single one) clearly improves image quality and the two multi-distance phase retrieval methods give similar results. First results on the segmentation of osteocyte lacunae and canaliculi from such images are presented.
机译：所有长度尺度的骨质对骨质疏松症等疾病的骨折风险都有重大影响。但是，在细胞尺度上关于骨组织的定量3D数据仍然很少。在此，我们建议在格勒诺布尔ESRF的光束线ID16A上开发的新装置上，使用放大的X射线相纳米CT定量人体骨骼中的骨超结构。要获得3D图像，需要在断层扫描重建之前应用相位检索。相位检索是一个不适定的问题，为此已经开发了各种方法。由于图像质量对骨组织的进一步量化有很大影响，因此我们的目的是评估在细胞规模上对骨样品成像的不同相位检索方法。使用放大相纳米CT在体素大小为120和30 nm的情况下以33 keV的能量扫描女性供体股骨的样品。对于每个样本，以不同的样本到检测器距离进行四次CT扫描。我们评估了适合这些条件的三种相位检索方法：单距离的Paganin方法，扩展到多个距离的Paganin方法以及纯相位对象的对比度传递函数（CTF）方法。这些方法被用作迭代优化步骤的初始化。我们基于视觉和定量评估的结果表明，使用多个距离（而不是单个距离）可以明显提高图像质量，并且两种多距离相位检索方法也得出相似的结果。提出了从此类图像分割骨细胞腔和小管的初步结果。

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  • 来源
    《Developments in X-ray tomography XI》|2017年|103910L.1-103910L.7|共7页
  • 会议地点 San Diego(US)
  • 作者

    Boliang Yu; Max Langer; Alexandra Pacureanu; Remy Gauthier; Helene Follet; David Mitton; Cecile Olivier; Peter Cloetens; Francoise Peyrin;

  • 作者单位

    Univ Lyon, INSA Lyon, Universite Claude Bernard Lyon 1, UJM-Saint Etienne, CNRS UMR 5220, Inserm U1206, CREATIS, Lyon, France;

    Univ Lyon, INSA Lyon, Universite Claude Bernard Lyon 1, UJM-Saint Etienne, CNRS UMR 5220, Inserm U1206, CREATIS, Lyon, France,ESRF, 38053 Grenoble Cedex, France;

    ESRF, 38053 Grenoble Cedex, France;

    Univ Lyon, Universite Claude Bernard Lyon 1, IFSTTAR, UMR_T9406, Lyon, France;

    Univ Lyon, Universite Claude Bernard Lyon 1, INSERM UMR 1033, Lyon, France;

    Univ Lyon, Universite Claude Bernard Lyon 1, IFSTTAR, UMR_T9406, Lyon, France;

    Univ Lyon, INSA Lyon, Universite Claude Bernard Lyon 1, UJM-Saint Etienne, CNRS UMR 5220, Inserm U1206, CREATIS, Lyon, France,ESRF, 38053 Grenoble Cedex, France;

    ESRF, 38053 Grenoble Cedex, France;

    Univ Lyon, INSA Lyon, Universite Claude Bernard Lyon 1, UJM-Saint Etienne, CNRS UMR 5220, Inserm U1206, CREATIS, Lyon, France,ESRF, 38053 Grenoble Cedex, France;

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  • 原文格式 PDF
  • 正文语种 eng
  • 中图分类
  • 关键词

    phase retrieval; X-ray nano-tomography; bone imaging; lacunae;

    机译：相位检索； X射线纳米断层扫描；骨成像；空白;

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