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Mapping the human atria with optical coherence tomography

机译：用光学相干断层扫描技术绘制人体心房图

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Atrial structure plays an important role in the mechanisms of atrial disease. However, detailed imaging of human atria remains limited due to many imaging modalities lacking sufficient resolution. We propose the use of optical coherence tomography (OCT), which has micrometer resolution and millimeter-scale imaging depth well-suited for the atria, combined with image stitching algorithms, to develop large, detailed atria image maps. Human atria samples (n = 7) were obtained under approved protocols from the National Disease Research Interchange (NDRI). One right atria sample was imaged using an ultrahigh-resolution spectral domain OCT system, with 5.52 and 2.72 µm lateral and axial resolution in air, respectively, and 1.78 mm imaging depth. Six left atria and five pulmonary vein samples were imaged using the spectral domain OCT system, Telesto I (Thorlabs GmbH, Germany) with 15 and 6.5 µm lateral and axial resolution in air, respectively, and 2.51 mm imaging depth. Overlapping image volumes were obtained from areas of the human left and right atria and the pulmonary veins. Regions of collagen, adipose, and myocardium could be identified within the OCT images. Image stitching was applied to generate fields of view with side dimensions up to about 3 cm. This study established steps towards mapping large regions of the human atria and pulmonary veins in high resolution using OCT.
机译：心房结构在心房疾病的发病机制中起着重要作用。但是，由于许多成像模式缺乏足够的分辨率，因此对人心房的详细成像仍然受到限制。我们建议使用光学相干断层扫描（OCT），它具有非常适合心房的微米分辨率和毫米级成像深度，并结合图像拼接算法来开发大型，详细的心房图像图。人心房样本（n = 7）是根据美国国家疾病研究交换所（NDRI）批准的协议获得的。使用超高分辨率光谱域OCT系统对一个右心房样本进行成像，其在空气中的横向和轴向分辨率分别为5.52和2.72 µm，成像深度为1.78 mm。使用光谱域OCT系统Telesto I（德国Thorlabs GmbH，德国）对六个左心房和五个肺静脉样本成像，空气中的横向和轴向分辨率分别为15和6.5 µm，成像深度为2.51 mm。从人的左右心房和肺静脉区域获得重叠的图像体积。在OCT图像中可以识别出胶原蛋白，脂肪和心肌区域。应用图像缝合以产生侧面尺寸最大约3 cm的视场。这项研究建立了使用OCT高分辨率绘制人类心房和肺静脉大区域的步骤。

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