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首页> 外文会议>Optical diagnostics and sensing XVIII: Toward Point-of-Care Diagnostics >Development of real-time and quantitative monitoring of thrombus formation in an extracorporeal centrifugal blood pump
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Development of real-time and quantitative monitoring of thrombus formation in an extracorporeal centrifugal blood pump

机译：实时和定量监测体外离心血泵中血栓形成的开发

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We developed an optical detector of thrombus formed on the pivot bearing of an extracorporeal centrifugal blood pump (MERA HCF-MP23; Senko Medical Instrument Mfg. Co., Ltd., Tokyo, Japan) which is frequently used for long-term extracorporeal circulation support to bridge to an implantable artificial heart, which in turn is used for bridge to heart transplantation in Japan. In this study, we investigated the quantitative performance of the thrombus formation in acute animal experiments. A total of three experiments of extracorporeal left ventricular assist using Japanese specific pathogen-free pigs were conducted. The optical fibers were set in the pump driver unit. The incident light at near-infrared wavelength aiming at the pivot bearing and the resulting scattered light were guided to respective fibers. The detected signal was analyzed to obtain thrombus formation level (TFL) calculated by a specially developed software. When the increase in TFL was confirmed, the pump was exchanged and the extracorporeal circulation was restarted. The number of pump exchanges were four times at each experiment so a total of twelve pumps were evaluated. 3-dimentional data surrounding the pivot bearing and the adhered thrombus was captured by a 3-dimantional surface measurement system to calculate the thrombus surface area (TSA) formed on the pivot bearing. As a result, the correlation coefficient between TFL and TSA was 0.878. The accuracy of TSA estimated by the optical detector was 3.6±2.3 mm~2. This was small enough to not have the pump exchanged in clinical judgement. The developed detector would be useful for optimal anti-coagulation management.
机译：我们开发了一种在体外离心血泵的枢轴轴承上形成的血栓光学检测器（MERA HCF-MP23；日本东京的Senko Medical Instrument Mfg。Co.，Ltd.），经常用于长期体外循环支持桥接到可植入的人造心脏，后者又在日本用于桥接心脏移植。在这项研究中，我们调查了急性动物实验中血栓形成的定量表现。使用日本无特定病原体的猪进行了总共三个体外左心室辅助实验。光纤设置在泵驱动器单元中。瞄准枢轴轴承的近红外波长的入射光和所产生的散射光被引导到各个光纤。分析检测到的信号以获得通过专门开发的软件计算出的血栓形成水平（TFL）。当确认TFL升高时，更换泵并重新开始体外循环。每个实验中泵更换次数为四次，因此总共评估了十二个泵。通过三维表面测量系统捕获围绕枢轴轴承和附着的血栓的3维数据，以计算在枢轴轴承上形成的血栓表面积（TSA）。结果，TFL和TSA之间的相关系数为0.878。光学探测器估计的TSA精度为3.6±2.3 mm〜2。这个小到不能在临床判断中更换泵。开发的检测器对于最佳抗凝管理将很有用。

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