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首页> 外文期刊>Artificial Organs >Optical Dynamic Analysis of Thrombus Inside a Centrifugal Blood Pump During Extracorporeal Mechanical Circulatory Support in a Porcine Model
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Optical Dynamic Analysis of Thrombus Inside a Centrifugal Blood Pump During Extracorporeal Mechanical Circulatory Support in a Porcine Model

机译：猪模型中体外机械循环载体中离心血泵内部血栓的光学动力学分析

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Complications due to pump thrombus remain the weak point of mechanical circulatory support (MCS), such as the use of a left ventricular assist device (LVAD) or extracorporeal membrane oxygenation, leading to poor outcomes. Hyperspectral imaging (HSI) is an effective imaging method using a hyperspectral (HS) camera, which comprises a spectrophotometer and a charge-coupled device camera to discriminate thrombus from whole blood. Animal experiments were conducted to analyze dynamic imaging of thrombus inside a prototype of a hydrodynamically levitated centrifugal blood pump using an HSI system. Six pigs were divided into a venous circulation group (n53) and an arterial circulation group (n53). Inflow and outflow cannulae were inserted into the jugular veins in the venous circulation group. The latter simulated an LVAD application. To create thrombogenic conditions, pump flow was maintained at 1 L/min without anticoagulation. An image of the bottom surface of the pump was captured by the HS camera every 4 nm over the wavelength range of 608-752 nm. Real-time dynamic images of the inside of the pump were displayed on the monitor. Appearance of an area displaying thrombus was detected within 24 h after the start of the circulation in every experiment. This imaging system also succeeded in determining the origins of pump thrombus: from inside the pump in two cases, and from outside in four cases. Two main possible sources of pump thrombus originating outside the pump were identified on autopsy: wedge thrombus around the inflow cannula; and string-like thrombus at the junction between the pump inlet and circuit tube. The results of this study from close observation of the changing appearance of pump thrombus may contribute to improvements in the safety of extracorporeal MCS.
机译：由于泵血栓引起的并发症仍然是机械循环支持（MCS）的弱点，例如使用左心室辅助装置（LVAD）或体外膜氧合，导致差的结果。高光谱成像（HSI）是使用高光谱（HS）相机的有效成像方法，该方法包括分光光度计和电荷耦合器件相机，以区分全血的血栓。使用HSI系统进行动物实验以分析流体动力学悬浮离心血泵原型内血栓的动态成像。将六只猪分为静脉循环基（N53）和动脉循环基团（N53）。将流入和流出套管插入静脉循环组中的颈静脉中。后者模拟了LVAD应用。为了产生血栓形成条件，泵流量在1升/分钟内保持，而不会抗凝血。通过HS相机在608-752nm的波长范围内每4nm捕获泵的底表面的图像。泵内部的实时动态图像显示在显示器上。在每个实验中循环开始后24小时内检测显示血栓的区域的外观。该成像系统还成功地确定了泵血栓的起源：在两种情况下从泵内部，在四个情况下从外部。源于泵外的两个主要可能的泵血栓源是在尸检上鉴定出来的：流入套管周围的楔形血栓;在泵入口和电路管之间的连接处和串状血栓。本研究从密切观察泵血栓的变化外观的结果可能有助于改善体外MCS的安全性。

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