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Whole-head functional brain imaging of neonates at cot-side using time-resolved diffuse optical tomography

机译:时间分辨扩散光学层析成像技术在婴儿床侧对新生儿进行全头功能脑成像

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摘要

We present a method for acquiring whole-head images of changes in blood volume and oxygenation from the infant brain at cot-side using time-resolved diffuse optical tomography (TR-DOT). At UCL, we have built a portable TR-DOT device, known as MONSTIR Ⅱ, which is capable of obtaining a whole-head (1024 channels) image sequence in 75 seconds. Datatypes extracted from the temporal point spread functions acquired by the system allow us to determine changes in absorption and reduced scattering coefficients within the interrogated tissue. This information can then be used to define clinically relevant measures, such as oxygen saturation, as well as to reconstruct images of relative changes in tissue chromophore concentration, notably those of oxy- and deoxyhaemoglobin. Additionally, the effective temporal resolution of our system is improved with spatio-temporal regularisation implemented through a Kalman filtering approach, allowing us to image transient haemodynamic changes. By using this filtering technique with intensity and mean time-of-flight datatypes, we have reconstructed images of changes in absorption and reduced scattering coefficients in a dynamic 2D phantom. These results demonstrate that MONSTIR Ⅱ is capable of resolving slow changes in tissue optical properties within volumes that are comparable to the preterm head. Following this verification study, we are progressing to imaging a 3D dynamic phantom as well as the neonatal brain at cot-side. Our current study involves scanning healthy babies to demonstrate the quality of recordings we are able to achieve in this challenging patient population, with the eventual goal of imaging functional activation and seizures.
机译:我们提出了一种使用时间分辨弥散光学层析成像(TR-DOT)从婴儿床侧婴儿床获取血容量和氧合变化的全头图像的方法。在UCL,我们构建了便携式TR-DOT设备,称为MONSTIRⅡ,该设备能够在75秒内获得全头(1024个通道)图像序列。从系统获取的时间点扩散函数中提取的数据类型使我们能够确定被询问组织内吸收的变化和散射系数的降低。然后,该信息可用于定义临床上相关的措施,例如氧饱和度,以及重建组织发色团浓度(尤其是氧合和脱氧血红蛋白的浓度)相对变化的图像。此外,通过卡尔曼滤波方法实现的时空正则化提高了我们系统的有效时间分辨率,使我们能够成像瞬态血流动力学变化。通过将这种滤波技术与强度和平均飞行时间数据类型结合使用,我们已经重建了动态2D体模中吸收变化和散射系数降低的图像。这些结果表明MONSTIRⅡ能够解决与早产儿相当的体积内组织光学特性的缓慢变化。经过这项验证研究,我们正在为3D动态体模以及婴儿床的新生儿大脑成像。我们当前的研究涉及扫描健康的婴儿,以证明我们能够在这一具有挑战性的患者人群中实现记录的质量,最终目标是对功能激活和癫痫发作进行成像。

著录项

  • 来源
    《Diffuse optical imaging V》|2015年|953818.1-953818.10|共10页
  • 会议地点 Munich(DE)
  • 作者单位

    Department of Medical Physics and Biomedical Engineering, University College London, London WC1E 6BT, UK;

    Department of Medical Physics and Biomedical Engineering, University College London, London WC1E 6BT, UK;

    Department of Medical Physics and Biomedical Engineering, University College London, London WC1E 6BT, UK,Department of Computer Science, University College London, London WC1E 6BT, UK;

    The Evelyn Perinatal Imaging Centre, Rosie Hospital, Cambridge University Hospitals NHS Foundation Trust, Cambridge CB2 0QQ, UK;

    The Evelyn Perinatal Imaging Centre, Rosie Hospital, Cambridge University Hospitals NHS Foundation Trust, Cambridge CB2 0QQ, UK;

    Department of Medical Physics and Biomedical Engineering, University College London, London WC1E 6BT, UK;

    Department of Medical Physics and Biomedical Engineering, University College London, London WC1E 6BT, UK;

    Department of Computer Science, University College London, London WC1E 6BT, UK;

    Department of Medical Physics and Biomedical Engineering, University College London, London WC1E 6BT, UK;

    The Evelyn Perinatal Imaging Centre, Rosie Hospital, Cambridge University Hospitals NHS Foundation Trust, Cambridge CB2 0QQ, UK;

    Department of Medical Physics and Biomedical Engineering, University College London, London WC1E 6BT, UK;

  • 会议组织
  • 原文格式 PDF
  • 正文语种 eng
  • 中图分类
  • 关键词

    Diffuse optical tomography; functional near infrared spectroscopy; time-resolved; time-domain;

    机译:漫射光学层析成像;功能近红外光谱时间解决时域;

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