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首页> 美国卫生研究院文献>Sensors (Basel Switzerland) >Real-Time Dual-Wavelength Time-Resolved Diffuse Optical Tomography System for Functional Brain Imaging Based on Probe-Hosted Silicon Photomultipliers
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Real-Time Dual-Wavelength Time-Resolved Diffuse Optical Tomography System for Functional Brain Imaging Based on Probe-Hosted Silicon Photomultipliers

机译：基于探头托管的硅光电倍增管的功能性脑成像实时双波长时间分辨漫射光学层析成像系统

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Near-infrared diffuse optical tomography is a non-invasive photonics-based imaging technology suited to functional brain imaging applications. Recent developments have proved that it is possible to build a compact time-domain diffuse optical tomography system based on silicon photomultipliers (SiPM) detectors. The system presented in this paper was equipped with the same eight SiPM probe-hosted detectors, but was upgraded with six injection fibers to shine the sample at several points. Moreover, an automatic switch was included enabling a complete measurement to be performed in less than one second. Further, the system was provided with a dual-wavelength (670 and 820 ) light source to quantify the oxy- and deoxy-hemoglobin concentration evolution in the tissue. This novel system was challenged against a solid phantom experiment, and two in-vivo tests, namely arm occlusion and motor cortex brain activation. The results show that the tomographic system makes it possible to follow the evolution of brain activation over time with a 1 -resolution.
机译：近红外漫射光学层析成像是一种非侵入性的，基于光子学的成像技术，适用于功能性大脑成像应用。最近的发展证明，有可能建立一种基于硅光电倍增管（SiPM）检测器的紧凑型时域漫射光学层析成像系统。本文介绍的系统配备了相同的8个SiPM探针托管检测器，但升级了6条注入光纤以使样品在多个点发光。此外，还包括一个自动开关，可以在不到一秒钟的时间内完成一次完整的测量。此外，该系统配备有双波长（670和820）光源，以量化组织中氧和脱氧血红蛋白浓度的变化。这个新系统受到实体模型实验和两项体内实验的挑战，即手臂闭塞和运动皮层大脑激活。结果表明，层析成像系统使得以1分辨率跟踪随时间变化的大脑激活成为可能。

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