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Effect of specimen size on cancellous bone microstructural parameters

机译：标本尺寸对松质骨微结构参数的影响

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As the average life span of Japanese people continues to extend, the increasing incidence of osteoporosis within the aging society is becoming a major public health problem. Such diseases have a negative impact on Quality of Life and an urgent issue to find prevention and treatment methods. Currently, correlation between the microstructural parameters and the mechanical properties is shown by using an X-ray microtomography. In this study, the influence of the cancellous bone region on the correlation between the microstructural parameters, calculated by using X-ray microtomography images, and Young's modulus, which were obtained from the compression test, was clarified by targeting cancellous bone specimens of various regions, obtained from bovine femur. Cancellous bone specimens were obtained from the right femur of a bovine for the compression test. The correlation coefficient between Young's modulus and microstructural parameters was calculated. Cubic specimen in 5mm had the highest correlation coefficient between Young's modulus and microstructural parameters. Additionally, when specimen regions were 4 or 5mm, the standard deviation of each microstructural parameter had the smallest value, except for Trabecular Separation and Mean Intercept Length 3. The cancellous bone region of the cubic specimen in 5mm had a high correlation between microstructural parameters and Young's modulus and the value of the microstructural parameters of the small variation.
机译：随着日本人的平均寿命不断延长，老龄化社会中骨质疏松症的发病率日益增加，已成为主要的公共卫生问题。这些疾病对生活质量有负面影响，是寻找预防和治疗方法的紧迫问题。当前，通过使用X射线显微断层摄影术来显示微观结构参数和机械性能之间的相关性。在这项研究中，通过针对不同区域的松质骨标本，弄清了松质骨区域对通过X射线显微断层扫描图像计算出的微结构参数与杨氏模量之间的相关性（通过压缩测试获得的影响） ，从牛股骨获得。从牛的右股骨获得松质骨标本进行压缩试验。计算了杨氏模量与微观结构参数之间的相关系数。 5mm的立方试样的杨氏模量与微观结构参数之间的相关系数最高。此外，当标本区域为4或5mm时​​，除了小梁间距和平均截距3以外，每个微结构参数的标准偏差都具有最小值。立方毫米标本的松质骨区域在5mm内与微结构参数之间的相关性很高。杨氏模量和微结构参数值的微小变化。

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