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首页> 外文会议>Conference on optical interactions with tissue and cells >Porcine Skin Damage Thresholds for Pulsed Nanosecond-Scale Laser Exposure at 1064-nm
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Porcine Skin Damage Thresholds for Pulsed Nanosecond-Scale Laser Exposure at 1064-nm

机译：脉冲纳秒级1064 nm激光暴露的猪皮肤损伤阈值

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Pulsed high-energy lasers operating in the near-infrared (NIR) band are increasingly being used in medical, industrial, and military applications, but there are little available experimental data to characterize their hazardous effects on skin tissue. The current American National Standard for the Safe Use of Lasers (ANSI Z136.1-2014) defines the maximum permissible exposure (MPE) on the skin as either a single-pulse or total exposure time limit. This study determined the minimum visible lesion (MVL) damage thresholds in Yucatan miniature pig skin for the single-pulse case and several multiple-pulse cases over a wide range of pulse repetition frequencies (PRFs) (10, 125, 2,000, and 10,000 Hz) utilizing nanosecond-scale pulses (10 or 60 ns). The thresholds are expressed in terms of the median effective dose (ED50) based on varying individual pulse energy with other laser parameters held constant. The results confirm a decrease in MVL threshold as PRF increases for exposures with a constant number of pulses, while also noting a PRF-dependent change in the threshold as a function of the number of pulses. Furthermore, this study highlights a change in damage mechanism to the skin from melanin-mediated photomechanical events at high irradiance levels and few numbers of pulses to bulk tissue photothermal additivity at lower irradiance levels and greater numbers of pulses. The observed trends exceeded the existing exposure limits by an average factor of 9.1 in the photothermally-damaged cases and 3.6 in the photomechanically-damaged cases.
机译：在医疗，工业和军事应用中越来越多地使用在近红外（NIR）波段工作的脉冲高能激光器，但是几乎没有可用的实验数据来表征其对皮肤组织的危害。当前的美国安全使用激光器国家标准（ANSI Z136.1-2014）将皮肤上的最大允许暴露（MPE）定义为单脉冲或总暴露时间限制。这项研究确定了在宽脉冲重复频率（PRF）（10、125、2,000和10,000 Hz）范围内的单脉冲病例和数个多脉冲病例的尤卡坦小型猪皮肤的最小可见病变（MVL）损伤阈值）利用纳秒级脉冲（10或60 ns）。阈值是根据中位数有效剂量（ED50）表示的，该值基于在不改变其他激光参数的情况下变化的单个脉冲能量。结果证实，对于恒定脉冲数的曝光，随着PRF的增加，MVL阈值会降低，同时还要注意阈值随脉冲数变化的PRF依赖性变化。此外，这项研究强调了在高辐照度和少量脉冲的情况下对皮肤的损伤机制从黑色素介导的光机械事件向较低辐照度和较大脉冲数的大体积组织光热加性的变化。在光热损坏的情况下，观察到的趋势超出现有暴露极限的平均系数为9.1，在光机械损坏的情况下，观察到的趋势超过了3.6。

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