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首页> 外文会议>International Conference on Algebraic Biology(AB 2007); 20070702-04; Castle of Hagenberg(AT) >Inference of Complex Regulatory Network for the Cell Cycle System in Saccharomyces Cerevisiae
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Inference of Complex Regulatory Network for the Cell Cycle System in Saccharomyces Cerevisiae

机译：酿酒酵母细胞周期系统复杂调控网络的推论

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摘要

Recently we developed a graphical chain modeling procedure to infer a network from expression profiles between different stages, according to the natural order. In this study, this procedure was applied to 796 gene expression profiles of cell-cycle related genes, which were experimentally identified to be transcribed among five cell-cycle phases. These phases were well characterized by the inferred network. In the G1 and S phases, almost all of the genes were related among them, even though limited numbers of genes were related to each other in the other phases. Furthermore, the inferred network indicated that some genes in the former phases have long-distance regulation throughout the cell cycle; however, the main regulatory system in the cell cycle occurred step by step in a manner. This approach provides us a comprehensive analysis of serial gene regulation in the cell cycle system.
机译：最近，我们开发了一种图形链建模程序，可以根据自然顺序从不同阶段之间的表达谱推断出网络。在这项研究中，此程序应用于细胞周期相关基因的796个基因表达谱，这些基因在实验上被确定为在五个细胞周期阶段之间转录。通过推断网络可以很好地表征这些阶段。在G1和S期，几乎所有的基因都相互关联，尽管在其他相中数量有限的基因彼此相关。此外，推测的网络表明，前阶段的某些基因在整个细胞周期中都具有远距离调控。然而，细胞周期中的主要调控系统却是逐步发生的。这种方法为我们提供了细胞周期系统中系列基因调控的全面分析。

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