首页> 外文会议>International Conference on Computational Science and Its Applications(ICCSA 2004) pt.2; 20040514-20040517; Assisi; IT >A Simple Data Analysis Method for Kinetic Parameters Estimation from Renal Measurements with a Three-Headed SPECT System
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A Simple Data Analysis Method for Kinetic Parameters Estimation from Renal Measurements with a Three-Headed SPECT System

机译:三头SPECT肾测量动力学参数的简单数据分析方法

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We present here a new method for the determination of renal kinetic parameters from time-activity curves (TACs) obtained in dynamic tomographic Nuclear Medicine studies. The method allows to achieve subsecond sampling rates when using three-headed Single Photon Emission Computed Tomography (SPECT) systems. We used three-projections data sets in order to directly reconstruct region-of-interest (ROI) contents and to achieve an accurate description of the TACs. By defining a kinetic model for the behavior of the tracer we were able to relate each sampling point of the renal TAC to the correspondent point of the plasmatic TAC (input function). We analyzed simulated projections in 81 cases of region segmentation errors: the values of the renal clearances were reproduced within about -12% and +4%. The vascular fractions were reproduced within the measurement errors.
机译:我们在这里提出一种新的方法,用于从动态层析X射线核医学研究中获得的时间活动曲线(TAC)确定肾脏动力学参数。使用三头单光子发射计算机断层扫描(SPECT)系统时,该方法可以实现亚秒级采样率。我们使用三投影数据集来直接重建感兴趣区域(ROI)的内容并获得TAC的准确描述。通过定义示踪剂行为的动力学模型,我们能够将肾脏TAC的每个采样点与血浆TAC的对应点(输入功能)相关联。我们分析了81例区域分割错误的模拟预测:肾脏清除率的再现值在-12%和+ 4%范围内。血管分数在测量误差内再现。

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