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A biphasic parameter estimation method for quantitative analysis of dynamic renal scintigraphic data

机译:动态肾闪烁显像数据定量分析的双相参数估计方法

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摘要

Dynamic renal scintigraphy is an established method in nuclear medicine, commonly used for the assessment of renal function. In this paper, a biphasic model fitting method is proposed for simultaneous estimation of both vascular and parenchymal parameters from renal scintigraphic data. These parameters include the renal plasma flow, vascular and parenchymal mean transit times, and the glomerular extraction rate. Monte Carlo simulation was used to evaluate the stability and confidence of the parameter estimates obtained by the proposed biphasic method, before applying the method on actual patient study cases to compare with the conventional fitting approach and other established renal indices. The various parameter estimates obtained using the proposed method were found to be consistent with the respective pathologies of the study cases. The renal plasma flow and extraction rate estimated by the proposed method were in good agreement with those previously obtained using dynamic computed tomography and magnetic resonance imaging.
机译:动态肾脏闪烁显像术是核医学中已建立的方法,通常用于评估肾功能。在本文中,提出了一种双相模型拟合方法,用于从肾脏闪烁显像数据中同时估算血管参数和实质参数。这些参数包括肾血浆流量,血管和实质平均通过时间以及肾小球提取率。在将方法应用于实际患者研究案例以与常规拟合方法和其他已建立的肾脏指标进行比较之前,使用蒙特卡洛模拟法评估通过建议的双相方法获得的参数估计值的稳定性和可信度。发现使用所提出的方法获得的各种参数估计与研究案例的各自病理学一致。通过提出的方法估算的肾血浆流量和提取率与先前使用动态计算机断层扫描和磁共振成像所获得的结果非常吻合。

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