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A Simple Data Analysis Method for Kinetic Parameters Estimation from Renal Measurements with a Three-Headed SPECT System

机译:三圈SPECT系统肾脏测量的动力学参数估计简单数据分析方法

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We present here a new method for the determination of renal kinetic parameters from time-activity curves (TACs) obtained in dynamic tomographic Nuclear Medicine studies. The method allows to achieve subsecond sampling rates when using three-headed Single Photon Emission Computed Tomography (SPECT) systems. We used three-projections data sets in order to directly reconstruct region-of-interest (ROI) contents and to achieve an accurate description of the TACs. By defining a kinetic model for the behavior of the tracer we were able to relate each sampling point of the renal TAC to the correspondent point of the plasmatic TAC (input function). We analyzed simulated projections in 81 cases of region segmentation errors: the values of the renal clearances were reproduced within about -12% and +4%. The vascular fractions were reproduced within the measurement errors.
机译:我们在此提出了一种从动态断层核医学研究中获得的时间活性曲线(TAC)测定肾动力学参数的新方法。该方法允许在使用三头单光子发射计算机断层扫描(SPECT)系统时实现伯级采样率。我们使用了三个投影数据集,以便直接重建兴趣区域(ROI)内容并实现TAC的准确描述。通过定义示踪剂行为的动力学模型,我们能够将肾TAC的每个采样点与等离子体TAC(输入功能)的相应点联系起来。我们分析了81例区域分割误差的模拟预测:肾间隙的值在约-12%和+ 4%内转载。在测量误差内再现血管级分。

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