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Reconstruction of embedded absorbers in random media with applications in noninvasive 3D imaging of skin lesions

机译:随机介质中嵌入吸收体的重建及其在皮肤损伤的无创3D成像中的应用

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Abstract: An optical backscatter measuring instrument called aNevoscope is being developed to non-invasivelydetermine 3D characteristics of skin lesions withapplications in the diagnosis of malignant melanoma.Optical images are obtained by transilluminating thelesion and imaging backscattered radiation emanatingfrom the skin surface. Such emission profiles containinformation about the absorption characteristics ofsub-surface structures. It is conceivable that suchprofiles can be used to reconstruct structuralinformation of inhomogeneities such as mole embedded inthe skin. Monte Carlo simulations of photon migrationare performed to simulate the radiation pattern ofbackscattered radiation imaged at the surface of themedium when a light source is placed directly on thesurface of the medium. In particular, simulations areperformed on media with single embedded absorbers. Thisis the simplest model of a mole embedded in human skin.Some reconstruction algorithms based on the differencein emission profiles is the presence and absence of theabsorber, are tested. A prototype Nevoscope presentlybeing used for visual examination is described.Heuristic reconstruction schemes using images obtainedfrom the Nevoscope are also presented.!27
机译:摘要:正在开发一种称为nevoscope的光学背向散射测量仪,以无创地确定皮肤病变的3D特征,并将其应用于恶性黑色素瘤的诊断中。光学图像是通过透射照明病变并成像从皮肤表面发出的背向散射辐射而获得的。这样的发射曲线包含有关次表面结构的吸收特性的信息。可以想到的是,这种轮廓可以用于重构不均匀性的结构信息,例如嵌入皮肤中的痣。当将光源直接放置在介质表面上时,进行了光子迁移的蒙特卡罗模拟,以模拟在theme表面成像的反向散射辐射的辐射方向图。特别地,在具有单个嵌入式吸收器的介质上进行模拟。这是在人体皮肤中嵌入痣的最简单模型。测试了一些基于发射曲线差异的重建算法,即是否存在吸收剂。描述了目前用于视觉检查的内窥镜原型,还提出了使用从内窥镜获得的图像的启发式重建方案!27

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