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首页> 外文会议>Laser Medicine and Surgery; Progress in Biomedical Optics and Imaging; vol.6 no.35 >Photodynamic Therapy for Implanted VX2 Tumor in Rabbit Brains
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Photodynamic Therapy for Implanted VX2 Tumor in Rabbit Brains

机译：光动力疗法治疗兔脑中植入的VX2肿瘤

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摘要

To evaluate the therapeutic effect and the safety of single photodynamic therapy (PDT) with hematoporphyrin derivative produced in China, 60 New Zealand adult rabbits with VX2 tumor implanted into the brain were divided randomly into non-PDT-group and PDT-group. 36 rabbits of the PDT-group were performed photodynamic therapy. The survival time, neurological deteriorations, intracranial pressure (ICP), histology, pathology, tumor volume and brain water content were measured. Other 12 rabbits were received hematoporphyrin derivative and light irradiation of the normal brain. The ICP, histology, pathology, and brain water content were measured. The result indicated that Simple PDT may elongate the average survival time of the rabbits with VX2 rumors significantly; kill tumor cells; cause transient brain edema and increase ICP, but it is safe to be used in treating brain tumor.
机译：为了评估在中国生产的血卟啉衍生物的单光动力疗法（PDT）的治疗效果和安全性，将60只植入VX2肿瘤的新西兰成年兔随机分为非PDT组和PDT组。对PDT-组的36只兔子进行了光动力治疗。测量存活时间，神经系统恶化，颅内压（ICP），组织学，病理学，肿瘤体积和脑含水量。另外12只兔子接受血卟啉衍生物和正常脑的光照射。测量了ICP，组织学，病理学和脑含水量。结果表明，单纯PDT可以明显延长VX2谣言家兔的平均生存时间。杀死肿瘤细胞；会引起短暂性脑水肿并增加ICP，但用于治疗脑瘤是安全的。

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