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首页> 外文会议>Mechanisms for low-light therapy VII >Pulsed vs. CW Low Level Light Therapy on Osteoarticular Signs and Symptoms in Limited Scleroderma (CREST Syndrome)
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Pulsed vs. CW Low Level Light Therapy on Osteoarticular Signs and Symptoms in Limited Scleroderma (CREST Syndrome)

机译：有限硬皮病（CREST综合征）的脉冲vs. CW低水平光疗法治疗骨关节体征和症状

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Limited cutaneous systemic sclerosis (lcSSc) was formerly known as CREST syndrome in reference to the associated clinical features: Calcinosis, Raynaud's phenomenon, Esophageal dysfunction, Sclerodactyly, and Telangiectasias. The transforming growth factor beta (TGF-8) has been identified has a major player in the pathogenic process, while low level light therapy (LLLT) has been shown to modulate this cytokine superfamily. This case study was conducted to assess the efficacy of 940nm using microsecond domain pulsing and continuous wave mode (CW) on osteoarticular signs and symptoms associated with lcSSc. The patient was treated two to three times a week for 13 weeks, using a sequential pulsing mode on one elbow, and a CW mode on the other. Efficacy assessments included inflammation, symptoms, pain, and health scales, patient satisfaction, clinical global impression, and adverse effects monitoring. Significant functional and morphologic improvements were observed after LLLT, with best results seen with the pulsing mode. No significant adverse effects were noted. Two mechanisms of action may be at play. The 940nm wavelength provides inside-out heating possibly vasodilating capillaries which in turn increases catabolic processes leading to a reduction of in situ calcinosis. LLLT may also improve symptoms by triggering a cascade of cellular reactions, including the modulation of inflammatory mediators.
机译：有限的皮肤系统性硬化症（lcSSc）以前因其相关的临床特征而被称为CREST综合征：钙化病，雷诺现象，食道功能障碍，巩膜炎和毛细血管扩张。已确定转化生长因子β（TGF-8）在致病过程中起主要作用，而低水平光疗法（LLLT）已显示出可调节该细胞因子超家族。本案例研究使用微秒域脉冲和连续波模式（CW）评估940nm对与lcSSc相关的骨关节体征和症状的疗效。该患者一周两次接受2至3次治疗，共13周，在一个肘部使用连续脉冲模式，在另一个肘部使用CW模式。功效评估包括炎症，症状，疼痛和健康程度，患者满意度，临床总体印象以及不良反应监测。 LLLT后观察到功能和形态的显着改善，以脉冲模式观察到最佳结果。没有发现明显的不良反应。可能有两种作用机理。 940nm波长提供了由内而外的加热，可能会扩张血管，进而增加分解代谢过程，从而减少原位钙化病。 LLLT还可以通过触发一系列细胞反应，包括调节炎症介质，来改善症状。

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