首页> 外文会议> >Automatic modelling of protein 3D structure Nucleoplasmin-like viral coat protein from Cucumber mosaic virus
【24h】

Automatic modelling of protein 3D structure Nucleoplasmin-like viral coat protein from Cucumber mosaic virus

机译:黄瓜花叶病毒的蛋白质3D结构核酸核蛋白样病毒外壳蛋白的自动建模

获取原文

摘要

Automatic comparative molecular modelling of viral coat protein performs the homology modelling in different steps. Protein sequence of Capsid protein (Cucumber mosaic virus strain As) shows identify homologous proteins with known 3D structures by using PSI-BLAST i.e. it shows similarity with capsid protein from Cucumber mosaic virus (strain fny). Through analysis we got Nucleoplasmin-like viral coat protein as a potential template through a very convenient user interface for target selection. Bioinformatics software tools can reveal in formation on many aspect of protein structure and function, such as protein interaction expression pattern, surface activity, binding sites, and electrostatic potentials. Study focused on computational approach to deciphering the sequence similarity, molecular modeling and their function of coat protein of cucumber mosaic virus (strain fny). The data generated from these assay is subsequently added to a searchable database that allows potential drug targets to identify.
机译:病毒外壳蛋白的自动比较分子建模可在不同步骤中执行同源性建模。衣壳蛋白(黄瓜花叶病毒菌株As)的蛋白序列显示通过使用PSI-BLAST鉴定具有已知3D结构的同源蛋白,即它与来自黄瓜花叶病毒(fny株)的衣壳蛋白相似。通过分析,我们通过非常方便的用户界面选择靶标,获得了核纤溶酶样病毒外壳蛋白作为潜在模板。生物信息学软件工具可以揭示蛋白质结构和功能的许多方面,例如蛋白质相互作用的表达方式,表面活性,结合位点和静电势。研究侧重于计算方法,以解析黄瓜花叶病毒(fny株)的外壳蛋白的序列相似性,分子模型及其功能。随后将这些测定产生的数据添加到可搜索的数据库中,以识别潜在的药物靶标。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱:kefu@zhangqiaokeyan.com

京公网安备:11010802029741号 ICP备案号:京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有
  • 客服微信

  • 服务号