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TCPL delivery system: the role of sustained delivery of testosterone enanthate on the fine structure of seminiferous tubule of adult male rats

机译：TCPL递送系统：持续递送庚酸酯庚酸酯对成年雄性大鼠生精小管精细结构的作用

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It is well documented that testosterone stimulates protein anabolism, muscular development, bone growth and increased metabolic rate. In addition, exogenous low level of testosterone can inhibit the secretion of gonadotropins by the anterior pituitary. The objective of this study was to investigate the effect of sustained delivery of testosterone enanthate (TE) on the testicular architecture by means of tricalcium phosphate lysine (TCPL). In this experiment adult male Sprague Dawley rats (250-300 g BW) were randomly divided into three equal groups (n=16). Rats in group I were implanted subcutaneously with TE loaded TCP implants (4-6 ng/ml). Rats in group II were implanted with sham TCP capsules, and rats in group III served as intact unimplanted controls. Surgical aseptic techniques were performed according to standard laboratory procedures. At the end of 2 and 4 weeks post implantation, 8 animals from each group were sacrificed and the testes were collected, weighted, and embedded for histopathological evaluations. The results of this study revealed the following: (i) Sustained delivery of TE reduced spermatogonia numbers in animals after 2 and 4 weeks by approximately 10% in comparison to control animals. (ii) The lumen of the tubules showed slight regression after 4 weeks of TE treatment. (iii) Overall decrease of the vasculature of the experimental animals was seen after 2 and continued through 4 weeks with an occasional increase of microvasculature seen in animals treated for 4 weeks with TE. (iv) Finally, the germinal epithelium showed significant reduction in secondary spermatocytes and conversion to mature sperm.
机译：众所周知，睾丸激素可刺激蛋白质合成代谢，肌肉发育，骨骼生长和新陈代谢速率增加。此外，外源性睾丸激素水平低可抑制垂体前叶分泌促性腺激素。这项研究的目的是调查赖氨酸磷酸三赖氨酸（TCPL）持续递送睾丸酮庚酸酯（TE）对睾丸结构的影响。在该实验中，将成年雄性Sprague Dawley大鼠（250-300g BW）随机分成三个相等的组（n ＝ 16）。 I组的大鼠皮下植入装有TE的TCP植入物（4-6 ng / ml）。 II组的大鼠植入了假TCP胶囊，III组的大鼠作为完整的未植入对照。根据标准实验室程序进行手术无菌技术。在植入后2和4周末，处死每组8只动物，并收集睾丸，称重并包埋以进行组织病理学评估。这项研究的结果揭示了以下内容：（i）与对照动物相比，持续递送TE在2周和4周后减少了动物的精原细胞数量，减少了约10％。 （ii）在经过4周的TE治疗后，肾小管的内腔显示出轻微的消退。 （iii）在2周后观察到实验动物的脉管系统总体下降，并且持续到4周，在用TE治疗4周的动物中偶尔观察到微脉管系统的增加。 （iv）最后，生发上皮显示继发精母细胞显着减少并转化为成熟精子。

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