• 主题
高级搜索  >
历史搜索 清空历史
首页> 外文学位 >Development of a three compartment oral sustained release delivery system for nifedipine: An in vitro and in vivo comparison with an osmotic pump delivery system, in the dog.
【24h】

Development of a three compartment oral sustained release delivery system for nifedipine: An in vitro and in vivo comparison with an osmotic pump delivery system, in the dog.

机译：硝苯地平三腔口服缓释递送系统的开发：在犬中与渗透泵递送系统的体外和体内比较。

获取原文
获取原文并翻译 | 示例
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

The "Triad Capsule" is thought to be a good candidate for development of a new "One-a-day", sustained release delivery system, for a variety of orally administered drugs. The "Triad Capsule" consists of three individual compartments. The first compartment is coated on the outside of the capsule. A hard gelatin capsule houses the remaining two compartments. The second compartment (granules) is the intermediate releasing compartment and the third is the sustained releasing compartment, in the form of pellets. In vitro the "Triad Capsule" delivered Nifedipine immediately and sustained its release for up to 18-20 h. In contrast, the GITS-Nifedipine (Procardia-XL{dollar}sp{lcub}circler{rcub}{dollar}) sustained the release of the drug in a zero-order manner, for 24 h, after an initial lag time of 2-4 h. In the present study, a four way cross-over study was performed in beagle dogs (n = 4), to compare the performance of radiolabelled "Triad Capsule" (30 mg) versus radiolabelled GITS-Nifedipine tablet (30mg), under fasted and fed conditions. Concentrations of Nifedipine (30-50 ng/mL) were detected immediately in the serum following the administration of the Triad Capsule and concentrations of 20-95 ng/mL were maintained for up to 24h. However, two hours post administration of the GITS, no Nifedipine was detected in the blood. Concentrations of 20-80 ng/mL were achieved from the GITS for the following six hours, but no drug was detected beyond 8 h post dose.; Under fed conditions both delivery systems resided in the stomach for periods exceeding 10h. The blood levels of Nifedipine, post administration of the Triad Capsule, reached concentrations of 15-40 ng/mL within the first hour. Also, from 8 h onwards, concentrations of Nifedipine (20-65 ng/mL) were maintained. In contrast, when the GITS tablets were administered to the dogs under fed conditions Nifedipine was released within the first hour. The GITS tablets were capable of sustaining concentrations in the range of 10-60 ng/mL in the blood for up to 24 h. These studies demonstrated that the Triad Capsule was a viable alternative to the GITS. Of particular interest, is the fact that the Triad Capsule exhibited a more consistent performance in the manner in which the drug was released and absorbed, compared to the GITS tablet.
机译：人们认为，“三合一胶囊”是开发适用于多种口服药物的新型“一日一日”缓释递送系统的良好候选者。 “三合一胶囊”由三个独立的隔室组成。第一隔室涂覆在胶囊的外部。硬明胶胶囊容纳其余两个隔室。第二小室（颗粒）是中间释放小室，第三小室是呈颗粒形式的持续释放小室。在体外，“ Triad胶囊”立即释放了硝苯地平，并持续释放长达18-20小时。相反，GITS-硝苯地平（Procardia-XL {dollar} sp {lcub} circler {rcub} {dollar}）在初始滞后时间为2后，以零级方式持续释放药物24小时。 -4小时在本研究中，对比格犬（n = 4）进行了四路交叉研究，比较了禁食和禁食下放射性标记的“ Triad胶囊”（30 mg）与放射性标记的GITS-硝苯地平片（30mg）的性能。喂食条件。服用Triad胶囊后立即在血清中检测到硝苯地平（30-50 ng / mL）的浓度，并维持20-95 ng / mL的浓度长达24小时。但是，施用GITS后两小时，血液中未检测到硝苯地平。在接下来的六个小时内，从GITS达到20-80 ng / mL的浓度，但在给药后8小时内未检测到药物。在喂食条件下，两个输送系统在胃中的停留时间均超过10小时。服用Triad胶囊后，硝苯地平的血液浓度在第一个小时内达到15-40 ng / mL的浓度。同样，从8小时开始，硝苯地平（20-65 ng / mL）的浓度保持不变。相反，当在进食条件下向狗施用GITS片剂时，硝苯地平在第一小时内释放。 GITS片剂能够在血液中维持10-60 ng / mL的浓度达24小时。这些研究表明，Triad胶囊是GITS的可行替代品。特别令人感兴趣的是，与GITS片剂相比，Triad胶囊在释放和吸收药物方面表现出更加一致的性能。

著录项

  • 作者

    Anwar, Hanan Sami.;

  • 作者单位

    University of Kentucky.;

  • 授予单位 University of Kentucky.;
  • 学科 Health Sciences Pharmacy.
  • 学位 Ph.D.
  • 年度 1997
  • 页码 143 p.
  • 总页数 143
  • 原文格式 PDF
  • 正文语种 eng
  • 中图分类 药剂学;
  • 关键词

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号