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首页> 外文会议>International symposium on halogenated persistent organic pollutants >MONO-ORTHO AND DI-ORTHO SUBSTITUTED PCB CONGENERS AND TYPE 2 DIABETES IN THE ANNISTON COMMUNITY HEALTH SURVEY
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MONO-ORTHO AND DI-ORTHO SUBSTITUTED PCB CONGENERS AND TYPE 2 DIABETES IN THE ANNISTON COMMUNITY HEALTH SURVEY

机译：单邻和二邻替代PCB同志和Anniston社区健康调查中的2型糖尿病

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Associations between the mono-ortho and di-ortho substituted polychlorinated biphenyls (PCBs) and the prevalence of type 2 diabetes were investigated in adult participants of the cross-sectional community study in Anniston, Alabama, where PCBs were produced between 1929 and 1972. Among study participants with PCB measurements, 205 were classified as having diabetes, 169 as having pre-diabetes and 392 were classified as not having diabetes. We excluded participants with pre-diabetes from the statistical analyses in this study. The median for the sum of mono-ortho PCBs was 1.07 ng/g whole weight for individuals with diabetes and 0.58 ng/g whole weight for those without diabetes. Similarly, in those with diabetes the median for di-ortho PCBs was higher than for those without diabetes (5.20 vs 3.43 ng/g whole weight). We found strong statistically significant associations between diabetes and the sum of mono-ortho PCBs for the second, third and fourth quartiles, relative to the first quartile, after adjustment for the diabetes risk factors in participants less than 55 years of age (OR=3.55 for the second, OR=2.66 for the third, and OR=4.16 for the fourth quartile). Similar, but somewhat weaker associations, were also observed for the di-ortho PCBs for the third and fourth quartiles (OR=1.95 and OR=3.19, respectively).
机译：在1929年至1972年间，在阿拉巴马州Anniston的横截面群落研究的成人参与者中研究了单邻和二邻取代的多氯联苯（PCB）和2型糖尿病患者的关联。研究与PCB测量的参与者，205分为患有糖尿病，169例，患有前糖尿病和392分属于患有糖尿病。从本研究中的统计分析中排除了糖尿病前的参与者。单次官方PCB的中位数为糖尿病的个体为1.07 ng / g全体重，对于没有糖尿病的人，患有0.58ng / g的整体重量。类似地，在糖尿病的那些中，Di-ortho PCB的中值高于没有糖尿病（5.20 Vs 3.43ng / g的全重）。我们发现糖尿病之间的强大统计学意义和第二个，第三和第四个四分位数的单邻胞嘧啶的总和，相对于第一个四分位数在参与者在不到55岁以下的参与者（或= 3.55）的糖尿病患者危险因素对于第三个四分位数的第三个，或= 2.66，或= 4.16）。对于第三和第四四分位数的二叔PCB（或分别分别为= 1.95和3.19），也观察到类似但有些较弱的关联。

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