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首页> 外文会议>Biomedical Engineering >PREPARATION, STRUCTURAL AND MECHANICAL CHARACTERIZATION OF POROUS HYDROXYAPATITE-GELATIN COMPOSITE SCAFFOLDS FOR BONE TISSUE ENGINEERING
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PREPARATION, STRUCTURAL AND MECHANICAL CHARACTERIZATION OF POROUS HYDROXYAPATITE-GELATIN COMPOSITE SCAFFOLDS FOR BONE TISSUE ENGINEERING

机译：用于骨组织工程的多孔羟基磷灰石-明胶复合支架的制备，结构和力学表征

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摘要

In this study, to mimic the mineral and organic component of natural bone, hydroxapatite[HA] and gelatin[GEL] composite scaffolds were prepared using solvent-casting method combined with freeze drying process. Glutaraldehyde[GA] was used as cross linking agent and the bisulfite sodium was used as excess GA discharger. With this technique, it is possible to produce scaffolds with mechanical and structural properties close to natural trabecular bone. The scaffold prepared has an open, interconnected porous structure with a pore size of 80-400 μm. It was found that the GEL/HA with ratio of 50wt% HA has the compressive modulus of ～10GPa , the ultimate compressive stress of ～ 32MPa and the elongation of ～ 3MPa similar to that of trabecular bone. The chemical bonding and the microstructure of the composites were investigated by FT-IR, SEM and Light microscopy. The porosity and the apparent density of 50wt% HA scaffold were calculated and it was found that the addition of HA content can reduce the water absorption and the porosity. The biological responses of scaffolds carried out by L929 fibroblast cell culture.
机译：为了模拟天然骨的矿物质和有机成分，采用溶剂浇铸法结合冷冻干燥法制备了羟基磷灰石[HA]和明胶[GEL]复合支架。戊二醛[GA]用作交联剂，亚硫酸氢钠用作过量的GA放电剂。利用这种技术，可以生产具有与天然小梁骨接近的机械和结构特性的支架。所制备的支架具有孔径为80-400μm的开放的，相互连接的多孔结构。研究发现，HA含量为50wt％的GEL / HA的压缩模量为〜10GPa，极限压缩应力为〜32MPa，伸长率约为〜3MPa，与小梁骨相似。通过FT-IR，SEM和光学显微镜对复合材料的化学键合和微观结构进行了研究。计算了50wt％HA支架的孔隙率和表观密度，发现添加HA含量可以降低吸水率和孔隙率。 L929成纤维细胞培养对支架的生物学反应。

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